1 Ocak 2019 Dergi makalesi Açık Erişim

Sigva, Zeynep Ozlem Dogan; Okcanoglu, Tugce Balci; Avci, Cigir Biray; Susluer, Sunde Yilmaz; Kayabasi, Cagla; Turna, Burak; Dodurga, Yavuz; Nazli, Oktay; Gunduz, Cumhur

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/73815</identifier>
  <creators>
    <creator>
      <creatorName>Sigva, Zeynep Ozlem Dogan</creatorName>
      <givenName>Zeynep Ozlem Dogan</givenName>
      <familyName>Sigva</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Okcanoglu, Tugce Balci</creatorName>
      <givenName>Tugce Balci</givenName>
      <familyName>Okcanoglu</familyName>
      <affiliation>Near East Univ, Vocat Sch Hlth Serv, Med Biol Dept, Nicosia, Cyprus</affiliation>
    </creator>
    <creator>
      <creatorName>Avci, Cigir Biray</creatorName>
      <givenName>Cigir Biray</givenName>
      <familyName>Avci</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Susluer, Sunde Yilmaz</creatorName>
      <givenName>Sunde Yilmaz</givenName>
      <familyName>Susluer</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kayabasi, Cagla</creatorName>
      <givenName>Cagla</givenName>
      <familyName>Kayabasi</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Med Biol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turna, Burak</creatorName>
      <givenName>Burak</givenName>
      <familyName>Turna</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Urol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dodurga, Yavuz</creatorName>
      <givenName>Yavuz</givenName>
      <familyName>Dodurga</familyName>
      <affiliation>Pamukkale Univ, Dept Med Biol, Fac Med, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nazli, Oktay</creatorName>
      <givenName>Oktay</givenName>
      <familyName>Nazli</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Urol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gunduz, Cumhur</creatorName>
      <givenName>Cumhur</givenName>
      <familyName>Gunduz</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Urol, Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Investigation Of The Synergistic Effects Of Paclitaxel And Herbal Substances And Endemic Plant Extracts On Cell Cycle And Apoptosis Signal Pathways In Prostate Cancer Cell Lines</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/73815</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.gene.2018.11.049</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Paclitaxel, which isolated from Taxes brevifolia, is recently started to be used against prostate cancer treatment and it is a very effective compound against cancer. In this study, we aimed to test the synergistic effect of two plant active compounds (sulphoraphane (SFN) and silymarin (SILY)) and several endemic plant species from Turkey (such as Phlomis leucophracta, Rubia davisiana, Alkanna tinctoria), which are known to have antic-arcinogenic effect on androgen-independent PC3 and DU145, and androgen-dependent VCaP prostate cancer cell lines, with paclitaxel on the expression of cell cycle signaling and apoptosis regulator genes.</description>
  </descriptions>
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