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Optimization of Different Surface Modifications for Binding of Tumor Cells in a Microfluidic Systems

Meco, Hanife Ecenur; Karadag, Aslihan; Omeroglu, Sevde; Aydemir, Gizem; Kocal, Gizem Calibasi; Oruc, Muhammed Enes; Uvet, Huseyin; Basbinar, Yasemin


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/72181</identifier>
  <creators>
    <creator>
      <creatorName>Meco, Hanife Ecenur</creatorName>
      <givenName>Hanife Ecenur</givenName>
      <familyName>Meco</familyName>
      <affiliation>Inst Hlth Sci, Translat Oncol Dept, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karadag, Aslihan</creatorName>
      <givenName>Aslihan</givenName>
      <familyName>Karadag</familyName>
      <affiliation>Inst Hlth Sci, Translat Oncol Dept, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Omeroglu, Sevde</creatorName>
      <givenName>Sevde</givenName>
      <familyName>Omeroglu</familyName>
      <affiliation>Inst Sci &amp; Technol, Chem Engn, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydemir, Gizem</creatorName>
      <givenName>Gizem</givenName>
      <familyName>Aydemir</familyName>
      <affiliation>Fac Mech Engn, Mechatron Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kocal, Gizem Calibasi</creatorName>
      <givenName>Gizem Calibasi</givenName>
      <familyName>Kocal</familyName>
      <affiliation>Dokuz Eylul Univ, Inst Oncol, Dept Translat Oncol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oruc, Muhammed Enes</creatorName>
      <givenName>Muhammed Enes</givenName>
      <familyName>Oruc</familyName>
      <affiliation>Inst Sci &amp; Technol, Chem Engn, Kocaeli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Uvet, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Uvet</familyName>
      <affiliation>Fac Mech Engn, Mechatron Dept, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Basbinar, Yasemin</creatorName>
      <givenName>Yasemin</givenName>
      <familyName>Basbinar</familyName>
      <affiliation>Inst Oncol, Dept Translat Oncol, Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Optimization Of Different Surface Modifications For Binding Of Tumor Cells In A Microfluidic Systems</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/72181</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.30621/jbachs.2019.601</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Objectives:Microfluidic technology is a fast-growing area and provide high-efficient MEMS (Micro-Electro-Mechanical-Systems) sensor integration platform that helps to advance healthcare systems. Due to proper the chemical and mechanical properties of polymers, PDMS (Polydimethylsiloxane) (6) and PMMA (Poly-methyl-methacrylate), they became on the best candidate for health care studies in microfluidic studies (7). Besides, they perform great optical properties for observation of living cell experiments. To increase their performance, surface interactions works with cells, modification techniques are widely used in microfluidic chips. In this paper, our primary purpose is to modify such polymers and glass with matrigel, PDA and APTES so as to increase cell-surface interaction.</description>
  </descriptions>
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