1 Ocak 2019 Dergi makalesi Açık Erişim

Sener, Elif Funda; Taheri, Serpil; Sahin, Mustafa Caglar; Bayramov, Keziban Korkmaz; Marasli, Mert Kahraman; Zararsiz, Gokmen; Mehmetbeyoglu, Ecmel; Oztop, Didem Behice; Canpolat, Mehmet; Canatan, Halit; Ozkul, Yusuf

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{
  "@context": "https://schema.org/", 
  "@id": 71487, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Sener, Elif Funda"
    }, 
    {
      "@type": "Person", 
      "name": "Taheri, Serpil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Van Ozalp Educ & Res Hosp, Van, Turkey", 
      "name": "Sahin, Mustafa Caglar"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Genome & Stem Cell Ctr GENKOK, TR-38039 Kayseri, Turkey", 
      "name": "Bayramov, Keziban Korkmaz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ordu Educ & Res Hosp, Ordu, Turkey", 
      "name": "Marasli, Mert Kahraman"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Fac Med, Dept Biostat, TR-38039 Kayseri, Turkey", 
      "name": "Zararsiz, Gokmen"
    }, 
    {
      "@type": "Person", 
      "name": "Mehmetbeyoglu, Ecmel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Med, Dept Child & Adolescent Psychiat, Ankara, Turkey", 
      "name": "Oztop, Didem Behice"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Fac Med, Dept Child Neurol, TR-38039 Kayseri, Turkey", 
      "name": "Canpolat, Mehmet"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Fac Med, Dept Med Biol, TR-38039 Kayseri, Turkey", 
      "name": "Canatan, Halit"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Erciyes Univ, Fac Med, Dept Med Genet, TR-38039 Kayseri, Turkey", 
      "name": "Ozkul, Yusuf"
    }
  ], 
  "datePublished": "2019-01-01", 
  "description": "Autism spectrum disorder (ASD) is characterized by repetitive stereotypic behaviors, restricted interests, social withdrawal, and communication deficits. Aggression and insensitivity to pain are largely unexplained in these cases. We analyzed nine mRNA expressions of the candidate genes related to aggression and insensitivity to pain in the peripheral blood of patients with ASD. Whole blood samples were obtained from 40 autistic patients (33 boys, 7 girls) and 50 age- and sex-matched controls (37 boys and 13 girls) to isolate RNA. Gene expression was assessed by quantitative Real-Time PCR (qRT-PCR) in the Erciyes University Genome and Stem Cell Center (GENKOK). All of the gene expressions except CRHR1 and SLC6A4 were found to be statistically different between the ASD patients and controls. Gene expression also differed according to gender. Alterations in the mRNA expression patterns of the HTR1E, OPRL1, OPRM1, TACR1, PRKG1, SCN9A and DRD4 genes provide further evidence for a relevant effect of the respective candidate genes on the pathophysiology of ASD. Future studies may determine the sensitivity of these candidate markers in larger samples including further neuropsychiatric diagnosis.", 
  "headline": "Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders", 
  "identifier": 71487, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Altered Global mRNA Expressions of Pain and Aggression Related Genes in the Blood of Children with Autism Spectrum Disorders", 
  "url": "https://aperta.ulakbim.gov.tr/record/71487"
}