1 Ocak 2019 Dergi makalesi Açık Erişim

Arslan, Tayfun; Cakir, Nezaket; Keles, Turgut; Yiklioglu, Zekeriya B.; Senturk, Murat

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    "creators": [
      {
        "name": "Arslan, Tayfun"
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      {
        "affiliation": "Giresun Univ, Fac Sci, Dept Chem, TR-28200 Giresun, Turkey", 
        "name": "Cakir, Nezaket"
      }, 
      {
        "affiliation": "Karadeniss Tech Univ, Fac Sci, Dept Chem, TR-61080 Trabzon, Turkey", 
        "name": "Keles, Turgut"
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      {
        "affiliation": "Karadeniss Tech Univ, Fac Sci, Dept Chem, TR-61080 Trabzon, Turkey", 
        "name": "Yiklioglu, Zekeriya B."
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      {
        "affiliation": "Ibrahim Cecen Univ Agri, Fac Pharm, Dept Basic Sci Pharm, TR-04100 Agri, Turkey", 
        "name": "Senturk, Murat"
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    "description": "In this study, 1,2,3-triazole substituted metal-free and metallo phthalocyanines (4, 5, 6) and their water soluble derivatives (4a, 5a, 6a) were designed, synthesized for the first time and tested in vitro on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes. Most phthalocyanines exhibited good inhibitory activities on these enzymes. Among the six phthalocyanines and starting compounds, 4a showed the most interesting profile as a submicromolar selective inhibitor of AChE (IC50 = 0.040 mu M) and 5a showed the most effective inhibitor of BChE (IC50 = 0.1198 mu M).", 
    "doi": "10.1016/j.bioorg.2019.103100", 
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      "title": "BIOORGANIC CHEMISTRY", 
      "volume": "90"
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    "title": "Triazole substituted metal-free, metallo-phthalocyanines and their water soluble derivatives as potential cholinesterases inhibitors: Design, synthesis and in vitro inhibition study"
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