1 Ocak 2019 Dergi makalesi Açık Erişim

Bulbul, Mehmet; Sinen, Osman; Izgut-Uysal, V. Nimet; Akkoyunlu, Goekhan; Ozturk, Saffet; Uysal, Fatma

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    <subfield code="a">Peripheral apelin mediates stress-induced alterations in gastrointestinal motor functions depending on the nutritional status</subfield>
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    <subfield code="p">CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY</subfield>
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    <subfield code="a">Exposure to stress induces gastrointestinal (GI) dysmotility. In rodents, acute restraint stress (ARS) inhibits gastric emptying (GE) and intestinal transit (IT) via central and peripheral corticotropin-releasing factor (CRF)-mediated pathways. Peripherally administered apelin-13 was shown to inhibit GI motor functions; moreover, stress-induced upregulation of gastric apelin content was demonstrated in rats suggesting that peripheral apelin may mediate stress-induced alterations in GI motility. We investigated the role of endogenous peripheral apelin in stress-induced GI dysfunction. GE, IT and gastro-duodenal fasting motility were measured in non-stressed (NS), CRF-injected and ARS-loaded rats. CRF and apelin receptor antagonists astressin or F13A was administered before ARS or peripheral CRF injection. Apelin and APJ receptor expressions were determined using immunohistochemistry and quantified by qRT-PCR. Double immunofluorescence was performed for enteric neuronal apelin. GE and IT were delayed by CRF and ARS. ARS-induced changes were attenuated by F13A, whereas astressin was ineffective. CRF-induced alterations in GE and IT were restored completely by astressin, while they were diminished by F13A. Antral phase III-like contractions were disturbed following ARS which were preserved by preadministration of astressin, but not F13A. CRF impaired gastric and duodenal fasting contractions, while these changes were not altered by F13A. ARS increased apelin expression in stomach and duodenum. Apelin immunoreactivity was detected in mucosa, smooth muscles and myenteric plexi, whereas dense APJ receptor expression was observed within tunica muscularis. APJ receptor was downregulated in rats fasted overnight. These results suggest that enteric apelin acts as an inhibitor stress mediator in the postprandial state.</subfield>
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    <subfield code="u">Akdeniz Univ, Dept Physiol, Fac Med, Antalya, Turkey</subfield>
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    <subfield code="a">Akkoyunlu, Goekhan</subfield>
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    <subfield code="u">Akdeniz Univ, Dept Physiol, Fac Med, Antalya, Turkey</subfield>
    <subfield code="a">Bulbul, Mehmet</subfield>
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