1 Ocak 2019 Dergi makalesi Açık Erişim

Nayman, Ayse Hande; Siginc, Halime; Zemheri, Ebru; Yencilek, Faruk; Yildirim, Asif; Telci, Dilek

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    "creators": [
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        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Kayisdagi Cad, TR-34755 Istanbul, Turkey", 
        "name": "Nayman, Ayse Hande"
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      {
        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Kayisdagi Cad, TR-34755 Istanbul, Turkey", 
        "name": "Siginc, Halime"
      }, 
      {
        "affiliation": "Umraniye Training & Res Hosp, Dept Pathol, Istanbul, Turkey", 
        "name": "Zemheri, Ebru"
      }, 
      {
        "affiliation": "Yeditepe Univ, Fac Sch Med, Yeditepe Univ Hosp, Istanbul, Turkey", 
        "name": "Yencilek, Faruk"
      }, 
      {
        "affiliation": "Medeniyet Univ, Fac Med, Dept Urol, Istanbul, Turkey", 
        "name": "Yildirim, Asif"
      }, 
      {
        "affiliation": "Yeditepe Univ, Fac Engn, Dept Genet & Bioengn, Kayisdagi Cad, TR-34755 Istanbul, Turkey", 
        "name": "Telci, Dilek"
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    "description": "Renal cell carcinoma (RCC) is the predominant type of kidney cancer. Mammalian target of rapamycin (mTOR) inhibitor everolimus is currently used as a second-line therapy for sorafenib or sunitinib-refractory metastatic RCC patients. The clinical limitation confronted during everolimus therapy is the onset of drug resistance that decreases the efficacy of the drug. Elevated level of anti-apoptotic Bcl-2 protein is proposed to be an emerging feedback loop for the acquired drug-resistance in various cancer types. In this study, the Bcl-2 inhibitor ABT-737 was used in combination with everolimus to enhance its anti-tumor effectiveness in everolimus-resistant RCC cell lines. Everolimus and ABT-737 combination synergistically led to a decrease in the proliferation of primary site A-498 and metastatic site Caki-1 RCC cell lines, which was accompanied by a reduction in protein levels of cell cycle and mTOR pathway proteins. In both RCC cell lines, everolimus-ABT-737 combination not only induced apoptosis, caspase and PARP-1 cleavage but also a decrease in Bcl-2 protein levels in parallel with a concomitant increase in Bim and Noxa levels.", 
    "doi": "10.7150/jca.29192", 
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    "journal": {
      "issue": "6", 
      "pages": "1466-1478", 
      "title": "JOURNAL OF CANCER", 
      "volume": "10"
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      "id": "cc-by"
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    "publication_date": "2019-01-01", 
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      "title": "Dergi makalesi", 
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    "title": "Dual-Inhibition of mTOR and Bcl-2 Enhances the Anti-tumor Effect of Everolimus against Renal Cell Carcinoma In Vitro and In Vivo"
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