1 Ocak 2019 Dergi makalesi Açık Erişim

Ayaz, Furkan; Isse, Qadar Ahmed; Kheeree, Rusmeenee; Ersan, Ronak Haj; Algul, Oztekin

DataCite XML

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/69581</identifier>
  <creators>
    <creator>
      <creatorName>Ayaz, Furkan</creatorName>
      <givenName>Furkan</givenName>
      <familyName>Ayaz</familyName>
      <affiliation>Mersin Univ, Biotechnol Dept, TR-33110 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isse, Qadar Ahmed</creatorName>
      <givenName>Qadar Ahmed</givenName>
      <familyName>Isse</familyName>
      <affiliation>Mersin Univ, Biotechnol Dept, TR-33110 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kheeree, Rusmeenee</creatorName>
      <givenName>Rusmeenee</givenName>
      <familyName>Kheeree</familyName>
      <affiliation>Mersin Univ, Biotechnol Dept, TR-33110 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ersan, Ronak Haj</creatorName>
      <givenName>Ronak Haj</givenName>
      <familyName>Ersan</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Algul, Oztekin</creatorName>
      <givenName>Oztekin</givenName>
      <familyName>Algul</familyName>
      <affiliation>Mersin Univ, Fac Pharm, Dept Pharmaceut Chem, TR-33169 Mersin, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Immunomodulatory And Immunostimulatory Effects Of Some Bisbenzoxazole Derivatives On Lipopolysaccharide Stimulated Mammalian Macrophages</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/69581</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.35333/jrp.2019.41</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Benzoxazoles and their derivatives have exerted anti-cancer and anti-inflammatory (immunomodulatory) potential due to their anti-proliferative effect on the cells. These molecules are DNA basebioisosteres, therefore, their mechanism of action could be by mimicking the structures of the DNA bases and halting the DNA polymerization processes. Based on their anti-proliferative effect, in our study we aimed to decipher the potential anti-inflammatory activities of unique bisbenzoxazole derivatives in vitro on mammalian macrophages. Being able to manipulate the inflammatory function of macrophages would enable the regulation of the immune response against danger stimuli. This would enable us better prognosis against different types of the diseases ranging from autoimmune disorders to cancer. Our results support the stark anti-inflammatory potential of bisbenzoxazole derivatives RHE 241 and RHE 248 in vitro on the LPS activated mammalian macrophages. After further delineation of their mechanism of action in vitro and their in vivo potency, these molecules could be utilized as potent anti-inflammatory medicines.</description>
  </descriptions>
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