1 Ocak 2019 Dergi makalesi Açık Erişim

Dursun, Erdinc; Alaylioglu, Merve; Bilgic, Basar; Hanagasi, Hasmet; Guervit, Hakan; Emre, Murat; Gezen-Ak, Duygu

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/68487</identifier>
  <creators>
    <creator>
      <creatorName>Dursun, Erdinc</creatorName>
      <givenName>Erdinc</givenName>
      <familyName>Dursun</familyName>
      <affiliation>Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Med Biol, Brain &amp; Neurodegenerat Disorders Res Lab, TR-34098 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Alaylioglu, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Alaylioglu</familyName>
      <affiliation>Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Med Biol, Brain &amp; Neurodegenerat Disorders Res Lab, TR-34098 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bilgic, Basar</creatorName>
      <givenName>Basar</givenName>
      <familyName>Bilgic</familyName>
      <affiliation>Istanbul Univ, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Hanagasi, Hasmet</creatorName>
      <givenName>Hasmet</givenName>
      <familyName>Hanagasi</familyName>
      <affiliation>Istanbul Univ, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guervit, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Guervit</familyName>
      <affiliation>Istanbul Univ, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Emre, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Emre</familyName>
      <affiliation>Istanbul Univ, Dept Neurol, Behav Neurol &amp; Movement Disorders Unit, Istanbul Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gezen-Ak, Duygu</creatorName>
      <givenName>Duygu</givenName>
      <familyName>Gezen-Ak</familyName>
      <affiliation>Istanbul Univ Cerrahpasa, Cerrahpasa Fac Med, Dept Med Biol, Brain &amp; Neurodegenerat Disorders Res Lab, TR-34098 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Amyloid Beta Adsorption Problem With Transfer Plates In Amyloid Beta 1-42 Ivd Kits</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/68487</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s12031-019-1261-0</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Adsorption of CSF A1-42 during pre-analytical processing is suggested as an important confounder in testing. The aim of the present study was to assess the effect of polypropylene transfer plates (PTP) in the INNOTEST A1-42 IVD-ELISA assay on A1-42 levels. CSF samples from 26 individuals with subjective cognitive impairment (SCI) and 25 patients with suspected neurodegenerative disorders were tested using four different lots of kits. A1-42 levels in all samples that were loaded onto the PTP were significantly lower than the levels in the same samples that were analyzed without prior loading onto the PTP. We found that the PTP may adsorb A1-42 in the range 7 to 69%. The diagnosis in 20% of patients and amyloid burden assessment in 23% of SCI patients had to be modified post hoc due to initial erroneously low amyloid levels. Using a PTP prior to loading the samples onto the INNOTEST A1-42 test plate may result in erroneously low A1-42 levels.</description>
  </descriptions>
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