1 Ocak 2019 Dergi makalesi Açık Erişim

Aydin, Sevtap; Bacanli, Merve; Anlar, Hatice Gul; Cal, Tugbagul; Ari, Nuray; Bucurgat, Ulku Undeger; Basaran, Arif Ahmet; Basaran, Nursen

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/67645</identifier>
  <creators>
    <creator>
      <creatorName>Aydin, Sevtap</creatorName>
      <givenName>Sevtap</givenName>
      <familyName>Aydin</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bacanli, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Bacanli</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Anlar, Hatice Gul</creatorName>
      <givenName>Hatice Gul</givenName>
      <familyName>Anlar</familyName>
      <affiliation>Zonguldak Bulent Ecevit Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-67100 Zonguldak, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cal, Tugbagul</creatorName>
      <givenName>Tugbagul</givenName>
      <familyName>Cal</familyName>
      <affiliation>Karadeniz Tech Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-61080 Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ari, Nuray</creatorName>
      <givenName>Nuray</givenName>
      <familyName>Ari</familyName>
      <affiliation>Ankara Univ, Dept Pharmacol, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bucurgat, Ulku Undeger</creatorName>
      <givenName>Ulku Undeger</givenName>
      <familyName>Bucurgat</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Basaran, Arif Ahmet</creatorName>
      <givenName>Arif Ahmet</givenName>
      <familyName>Basaran</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmacognosy, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Basaran, Nursen</creatorName>
      <givenName>Nursen</givenName>
      <familyName>Basaran</familyName>
      <affiliation>Hacettepe Univ, Dept Pharmaceut Toxicol, Fac Pharm, TR-06100 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Preventive Role Of Pycnogenol (R) Against The Hyperglycemia-Induced Oxidative Stress And Dna Damage In Diabetic Rats</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/67645</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.fct.2018.11.038</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Diabetes mellitus, a complex progressive metabolic disorder, leads to some oxidative stress related complications. Pycnogenol (R) (PYC), a plant extract obtained from Pinus pinaster, has been suggested to be effective in many diseases including diabetes, cancer, inflammatory and immune system disorders. The mechanisms underlying the effects of PYC in diabetes need to be elucidated. The aim of this study was to determine the effects of PYC treatment (50 mg/kg/day, orally, for 28 days) on the DNA damage and biochemical changes in the blood, liver, and kidney tissues of experimental diabetic rats. Changes in the activities of catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase, and glutathione-S-transferase enzymes, and the levels of 8-hydroxy-2'-deoxyguanosine, total glutathione, malondialdehyde, insulin, total bilirubin, alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, high density lipoprotein, low density lipoprotein, total cholesterol, and triglyceride were evaluated. DNA damage was also determined in the whole blood cells and the liver and renal tissue cells using the alkaline comet assay. PYC treatment significantly ameliorated the oxidative stress, lipid profile, and liver function parameters as well as DNA damage in the hyperglycemic rats. The results show that PYC treatment might improve the hyperglycemia-induced biochemical and physiological changes in diabetes.</description>
  </descriptions>
</resource>