1 Ocak 2019 Dergi makalesi Açık Erişim

Kocaturk, Nur Mehpare; Akkoc, Yunus; Kig, Cenk; Bayraktar, Oznur; Gozuacik, Devrim; Kutlu, Ozlem

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/67343</identifier>
  <creators>
    <creator>
      <creatorName>Kocaturk, Nur Mehpare</creatorName>
      <givenName>Nur Mehpare</givenName>
      <familyName>Kocaturk</familyName>
      <affiliation>Sabanci Univ, Nanotechnol Res &amp; Applicat Ctr SUNUM, Orta Mah Univ Cad 27, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akkoc, Yunus</creatorName>
      <givenName>Yunus</givenName>
      <familyName>Akkoc</familyName>
      <affiliation>Sabanci Univ, Mol Biol Genet &amp; Bioengn Program, Fac Engn &amp; Nat Sci, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kig, Cenk</creatorName>
      <givenName>Cenk</givenName>
      <familyName>Kig</familyName>
      <affiliation>Istanbul Yeni Yuzyil Univ, Fac Med, TR-34010 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bayraktar, Oznur</creatorName>
      <givenName>Oznur</givenName>
      <familyName>Bayraktar</familyName>
      <affiliation>Okan Univ, Dept Med Biol &amp; Genet, Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gozuacik, Devrim</creatorName>
      <givenName>Devrim</givenName>
      <familyName>Gozuacik</familyName>
    </creator>
    <creator>
      <creatorName>Kutlu, Ozlem</creatorName>
      <givenName>Ozlem</givenName>
      <familyName>Kutlu</familyName>
      <affiliation>Sabanci Univ, Nanotechnol Res &amp; Applicat Ctr SUNUM, Orta Mah Univ Cad 27, TR-34956 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Autophagy As A Molecular Target For Cancer Treatment</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2019</publicationYear>
  <dates>
    <date dateType="Issued">2019-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/67343</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejps.2019.04.011</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Autophagy is an evolutionarily conserved catabolic mechanism, by which eukaryotic cells recycle or degrades internal constituents through membrane-trafficking pathway. Thus, autophagy provides the cells with a sustainable source of biomolecules and energy for the maintenance of homeostasis under stressful conditions such as tumor microenvironment. Recent findings revealed a close relationship between autophagy and malignant transformation. However, due to the complex dual role of autophagy in tumor survival or cell death, efforts to develop efficient treatment strategies targeting the autophagy/cancer relation have largely been unsuccessful. Here we review the two-faced role of autophagy in cancer as a tumor suppressor or as a pro-oncogenic mechanism. In this sense, we also review the shared regulatory pathways that play a role in autophagy and malignant transformation. Finally, anti-cancer therapeutic agents used as either inhibitors or inducers of autophagy have been discussed.</description>
  </descriptions>
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