1 Ocak 2020 Dergi makalesi Açık Erişim

Temel, Sehime Gulsun; Giray, Asli; Karakas, Bahriye; Gul, Ozgur; Kozanoglu, Ilknur; Celik, Husnu; Basaga, Huveyda; Acikbas, Ufuk; Sucularli, Ceren; Oztop, Sidika; Aka, Yeliz; Kutuk, Ozgur

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/6503</identifier>
  <creators>
    <creator>
      <creatorName>Temel, Sehime Gulsun</creatorName>
      <givenName>Sehime Gulsun</givenName>
      <familyName>Temel</familyName>
      <affiliation>Uludag Univ, Sch Med, Dept Med Genet, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Giray, Asli</creatorName>
      <givenName>Asli</givenName>
      <familyName>Giray</familyName>
      <affiliation>Alanya Alaaddin Keykubat Univ, Dept Genet &amp; Bioengn, Alanya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karakas, Bahriye</creatorName>
      <givenName>Bahriye</givenName>
      <familyName>Karakas</familyName>
      <affiliation>Sabanci Univ, Mol Biol Genet &amp; Bioengn Program, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gul, Ozgur</creatorName>
      <givenName>Ozgur</givenName>
      <familyName>Gul</familyName>
      <affiliation>Bilgi Univ, Dept Genet &amp; Bioengn, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kozanoglu, Ilknur</creatorName>
      <givenName>Ilknur</givenName>
      <familyName>Kozanoglu</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Physiol, Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Celik, Husnu</creatorName>
      <givenName>Husnu</givenName>
      <familyName>Celik</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Obstet &amp; Gynecol, Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Basaga, Huveyda</creatorName>
      <givenName>Huveyda</givenName>
      <familyName>Basaga</familyName>
      <affiliation>Sabanci Univ, Mol Biol Genet &amp; Bioengn Program, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Acikbas, Ufuk</creatorName>
      <givenName>Ufuk</givenName>
      <familyName>Acikbas</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Immunol, Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sucularli, Ceren</creatorName>
      <givenName>Ceren</givenName>
      <familyName>Sucularli</familyName>
      <affiliation>Hacettepe Univ, Inst Hlth Sci, Dept Bioinformat, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Oztop, Sidika</creatorName>
      <givenName>Sidika</givenName>
      <familyName>Oztop</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Immunol, Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aka, Yeliz</creatorName>
      <givenName>Yeliz</givenName>
      <familyName>Aka</familyName>
      <affiliation>Baskent Univ, Adana Dr Turgut Noyan Med &amp; Res Ctr, Dept Immunol, Adana, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kutuk, Ozgur</creatorName>
      <givenName>Ozgur</givenName>
      <familyName>Kutuk</familyName>
    </creator>
  </creators>
  <titles>
    <title>Rab25 Confers Resistance To Chemotherapy By Altering Mitochondrial Apoptosis Signaling In Ovarian Cancer Cells</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/6503</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10495-020-01635-z</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Ovarian cancer remains one of the most frequent causes of cancer-related death in women. Many patients with ovarian cancer suffer from de novo or acquired resistance to chemotherapy. Here, we report that RAB25 suppresses chemotherapy-induced mitochondrial apoptosis signaling in ovarian cancer cell lines and primary ovarian cancer cells. RAB25 blocks chemotherapy-induced apoptosis upstream of mitochondrial outer membrane permeabilization by either increasing antiapoptotic BCL-2 proteins or decreasing proapoptotic BCL-2 proteins. In particular, BAX expression negatively correlates with RAB25 expression in ovarian cancer cells. BH3 profiling assays corroborated that RAB25 decreases mitochondrial cell death priming. Suppressing RAB25 by means of RNAi or RFP14 inhibitory hydrocarbon-stapled peptide sensitizes ovarian cancer cells to chemotherapy as well as RAB25-mediated proliferation, invasion and migration. Our data suggest that RAB25 is a potential therapeutic target for ovarian cancer.</description>
  </descriptions>
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