1 Ocak 2020 Dergi makalesi Açık Erişim

Tektemur, Ahmet; Etem Onalan, Ebru; Kaya Tektemur, Nalan; Dayan Cinkara, Serap; Kilincli cetin, Ayten; Tekedereli, Ibrahim; Kuloglu, Tuncay; Turk, Gaffari

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/6347</identifier>
  <creators>
    <creator>
      <creatorName>Tektemur, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Tektemur</familyName>
      <affiliation>Firat Univ, Dept Med Biol, Fac Med, TR-23119 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Etem Onalan, Ebru</creatorName>
      <givenName>Ebru</givenName>
      <familyName>Etem Onalan</familyName>
      <affiliation>Firat Univ, Dept Med Biol, Fac Med, TR-23119 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kaya Tektemur, Nalan</creatorName>
      <givenName>Nalan</givenName>
      <familyName>Kaya Tektemur</familyName>
      <affiliation>Firat Univ, Dept Histol &amp; Embryol, Fac Med, Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Dayan Cinkara, Serap</creatorName>
      <givenName>Serap</givenName>
      <familyName>Dayan Cinkara</familyName>
      <affiliation>Firat Univ, Fac Vet Med, Dept Reprod &amp; Artificial Inseminat, Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kilincli cetin, Ayten</creatorName>
      <givenName>Ayten</givenName>
      <familyName>Kilincli cetin</familyName>
      <affiliation>Inonu Univ, Fac Med, Dept Med Biol &amp; Genet, Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekedereli, Ibrahim</creatorName>
      <givenName>Ibrahim</givenName>
      <familyName>Tekedereli</familyName>
      <affiliation>Inonu Univ, Fac Med, Dept Med Biol &amp; Genet, Malatya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kuloglu, Tuncay</creatorName>
      <givenName>Tuncay</givenName>
      <familyName>Kuloglu</familyName>
      <affiliation>Firat Univ, Dept Histol &amp; Embryol, Fac Med, Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turk, Gaffari</creatorName>
      <givenName>Gaffari</givenName>
      <familyName>Turk</familyName>
      <affiliation>Firat Univ, Fac Vet Med, Dept Reprod &amp; Artificial Inseminat, Elazig, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Carbamazepine-Induced Sperm Disorders Can Be Associated With The Altered Expressions Of Testicular Kcnj11/Mir-Let-7A And Spermatozoal Cftr/Mir-27A</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/6347</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1111/and.13954</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Male infertility is a global health problem, and the underlying molecular mechanisms are not clearly known. Ion channels and microRNAs (miRNAs), known to function in many vital functions in cells, have been shown to play a significant role in male infertility through changes in their expressions. The study aimed to evaluate the alterations of testicular and/or spermatozoal potassium voltage-gated channel subfamily J member 11 (KCNJ11), Cystic fibrosis transmembrane conductance regulator (CFTR), miR-let-7a and miR-27a expressions in carbamazepine-related male infertility. Here, we showed that carbamazepine reduced sperm motility, increased abnormal sperm morphology, and impaired hormonal balance as well as increased relative testis weight and decreased relative seminal vesicle weight. On the other hand, downregulated KCNJ11 and upregulated miR-let-7a expressions were determined in testis (p &amp;lt; .05). Also, downregulated KCNJ11 and upregulated CFTR and miR-27a expressions were found in spermatozoa (p &amp;lt; .05). Interestingly, altered testicular KCNJ11 and miR-let-7a expressions were correlated with decreased sperm motility and elevated sperm tail defect. Besides, spermatozoal CFTR and miR-27a expressions positively correlated with sperm tail defects. The results indicated a significant relationship between ion channel and/or miRNA expression alterations and impaired sperm parameters due to carbamazepine usage.</description>
  </descriptions>
</resource>