Dergi makalesi Açık Erişim
Ozbilgin, Ahmet; Durmuskahya, Cenk; Kayalar, Husniye; Ostan, Ipek
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Assessment of in vivo antimalarial activities of some selected medicinal plants from Turkey</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">PARASITOLOGY RESEARCH</subfield> <subfield code="v">113</subfield> <subfield code="n">1</subfield> <subfield code="c">165-173</subfield> </datafield> <controlfield tag="001">62119</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Resistant infections lead to increased necessity of searching novel drugs and drug combinations. The purpose of this paper was to investigate antimalarial properties of some selected medicinal plants that have been traditionally used in Turkey for antipyretic and analgesic purposes. Lavandula stoecheas subsp. cariensis, Phlomis nissolii, Phlomis bourgaei, Phlomis leucophracta, Centaurea hierapolitana, Centaurea polyclada, Centaurea lydia, Scrophularia cryptophila, Scrophularia depauperata, Scrophularia floribunda, Rubia davisiana, and Alkanna tinctoria subsp. subleiocarpa were investigated for their in vivo antimalarial activities in mice infected with Plasmodium yoelii. Two hundred fifty to 500 mg/kg doses of plant extracts were given to mice as a single daily dose for 4 days. P. nissolii water extract, C. lydia chloroform extract, S. cryptophila ethanol extract, and C. polyclada methanol extract showed antimalarial activity with reducing parasitaemia. The chemotherapeutic effects of plant extracts ranged between 13.5 % and 66.91 %. The chemosuppressions exerted by combined plant extracts of P. nissolii, S. cryptophila, and C. lydia with C. polyclada methanol extract were detected as 51.25 %, 57.33 %, and 58.33 %, respectively. Investigation of cytotoxic activities against brine shrimps revealed that methanol extract of C. polycada, chloroform extract of C. lydia, and ethanol extract of S. cryptophila showed cytotoxic activities, while water extract of P. nissolii was not active against brine shrimps.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Celal Bayar Univ, Sch Appl Sci, Fac Educ, Demirci Manisa, Turkey</subfield> <subfield code="a">Durmuskahya, Cenk</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Ege Univ, Fac Pharm, Dept Pharmacognosy, Izmir, Turkey</subfield> <subfield code="a">Kayalar, Husniye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Celal Bayar Univ, Vocat Sch Hlth Serv, Manisa, Turkey</subfield> <subfield code="a">Ostan, Ipek</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Celal Bayar Univ, Fac Med, Dept Parasitol, Manisa, Turkey</subfield> <subfield code="a">Ozbilgin, Ahmet</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2014-01-01</subfield> </datafield> <controlfield tag="005">20210316012229.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:62119</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:6fa04fce91899085a7c8060c8df6aed2</subfield> <subfield code="s">195</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/62119/files/bib-3321119b-b46b-4f2d-a4d6-f8c0abf44920.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1007/s00436-013-3639-1</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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