1 Ocak 2016 Dergi makalesi Açık Erişim

Alacam, Huseyin; Akgun, Sakir; Akca, Hakan; Ozturk, Onder; Kabukcu, Burge Basay; Herken, Hasan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/59561</identifier>
  <creators>
    <creator>
      <creatorName>Alacam, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Alacam</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Psychiat, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akgun, Sakir</creatorName>
      <givenName>Sakir</givenName>
      <familyName>Akgun</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Med Biol, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akca, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Akca</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Med Biol, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozturk, Onder</creatorName>
      <givenName>Onder</givenName>
      <familyName>Ozturk</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Child &amp; Adolescent Psychiat, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kabukcu, Burge Basay</creatorName>
      <givenName>Burge Basay</givenName>
      <familyName>Kabukcu</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Child &amp; Adolescent Psychiat, Denizli, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Herken, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Herken</familyName>
      <affiliation>Pamukkale Univ, Fac Med, Dept Psychiat, Denizli, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Mir-181B-5P, Mir-195-5P And Mir-301A-3P Are Related With Treatment Resistance In Schizophrenia</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/59561</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.psychres.2016.08.037</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The aim of the study was to determine the differences between expression levels of certain miRNAs, as their association with schizophrenia has been well presented in the literature, and to investigate their relation to treatment resistance in schizophrenic patients. Three groups were formed: 1) treatment resistant group, 2) treatment responsive group and 3) healthy control group. Expression levels of miRNAs from peripheric blood samples were determined by real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR). We investigated the roles of 29 schizophrenia-related miRNAs in schizophrenia treatment and their potentials to be considered as indicators. Among these miRNAs, only miR-181b-5p, miR-195-5p and miR-301a-3p expressions were found to be significantly different between the treatment-resistant group and the group responding well to the treatment miRNAs may cause resistance by silencing the receptor genes of the drugs used for schizophrenia treatment. miR-181b-5p, miR-195-5p and miR-301a-3p may be candidate indicators that can be used to reveal resistance against schizophrenia treatment. (C) 2016 Elsevier Ireland Ltd. All rights reserved.</description>
  </descriptions>
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