1 Ocak 2020 Dergi makalesi Açık Erişim

Barreca, Marilia; Spane, Virginia; Montalbano, Alessandra; Cueto, Mercedes; Marrero, Ana R. Diaz; Deniz, Irem; Erdogan, Aysegul; Bilela, Lada Lukic; Moulin, Corentin; Taffin-de-Givenchy, Elisabeth; Spriano, Filippo; Perale, Giuseppe; Mehiri, Mohamed; Rotter, Ana; Thomas, Olivier P.; Barraja, Paola; Gaudencio, Susana P.; Bertoni, Francesco

JSON-LD (schema.org)

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  "@context": "https://schema.org/", 
  "@id": 5907, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "Barreca, Marilia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, I-90123 Palermo, Italy", 
      "name": "Spane, Virginia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, I-90123 Palermo, Italy", 
      "name": "Montalbano, Alessandra"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Inst Prod Nat & Agrobiol IPNA CSIC, Tenerife 38206, Spain", 
      "name": "Cueto, Mercedes"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ La Laguna ULL, Inst Univ Bioorgan Antonio Gonzalez IUBO AG, Tenerife 38200, Spain", 
      "name": "Marrero, Ana R. Diaz"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Manisa Celal Bayar Univ, Fac Engn, Dept Bioengn, TR-45119 Manisa, Turkey", 
      "name": "Deniz, Irem"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ Applicat, Res Ctr Testing & Anal EGE MATAL, TR-35100 Izmir, Turkey", 
      "name": "Erdogan, Aysegul"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Sarajevo, Fac Sci, Dept Biol, Sarajevo 71000, Bosnia & Herceg", 
      "name": "Bilela, Lada Lukic"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Cote dAzur, CNRS, Inst Chim Nice, Marine Nat Prod Team,UMR 7272, F-06108 Nice, France", 
      "name": "Moulin, Corentin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Cote dAzur, CNRS, Inst Chim Nice, Marine Nat Prod Team,UMR 7272, F-06108 Nice, France", 
      "name": "Taffin-de-Givenchy, Elisabeth"
    }, 
    {
      "@type": "Person", 
      "affiliation": "USI, Inst Oncol Res, Fac Biomed Sci, CH-6500 Bellinzona, Switzerland", 
      "name": "Spriano, Filippo"
    }, 
    {
      "@type": "Person", 
      "name": "Perale, Giuseppe"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Cote dAzur, CNRS, Inst Chim Nice, Marine Nat Prod Team,UMR 7272, F-06108 Nice, France", 
      "name": "Mehiri, Mohamed"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Natl Inst Biol, Marine Biol Stn Piran, Ljubljana 1000, Slovenia", 
      "name": "Rotter, Ana"
    }, 
    {
      "@type": "Person", 
      "name": "Thomas, Olivier P."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, I-90123 Palermo, Italy", 
      "name": "Barraja, Paola"
    }, 
    {
      "@type": "Person", 
      "affiliation": "NOVA Univ Lisbon, Fac Sci & Technol, Blue Biotechnol & Biomed Lab, UCIBIO Appl Biomol Sci Unit,Dept Chem, P-2829516 Caparica, Portugal", 
      "name": "Gaudencio, Susana P."
    }, 
    {
      "@type": "Person", 
      "name": "Bertoni, Francesco"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "The marine environment is a rich source of biologically active molecules for the treatment of human diseases, especially cancer. The adaptation to unique environmental conditions led marine organisms to evolve different pathways than their terrestrial counterparts, thus producing unique chemicals with a broad diversity and complexity. So far, more than 36,000 compounds have been isolated from marine micro- and macro-organisms including but not limited to fungi, bacteria, microalgae, macroalgae, sponges, corals, mollusks and tunicates, with hundreds of new marine natural products (MNPs) being discovered every year. Marine-based pharmaceuticals have started to impact modern pharmacology and different anti-cancer drugs derived from marine compounds have been approved for clinical use, such as: cytarabine, vidarabine, nelarabine (prodrug of ara-G), fludarabine phosphate (pro-drug of ara-A), trabectedin, eribulin mesylate, brentuximab vedotin, polatuzumab vedotin, enfortumab vedotin, belantamab mafodotin, plitidepsin, and lurbinectedin. This review focuses on the bioactive molecules derived from the marine environment with anticancer activity, discussing their families, origin, structural features and therapeutic use.", 
  "headline": "Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes", 
  "identifier": 5907, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Marine Anticancer Agents: An Overview with a Particular Focus on Their Chemical Classes", 
  "url": "https://aperta.ulakbim.gov.tr/record/5907"
}