1 Ocak 2020 Dergi makalesi Açık Erişim

Bulut, Esin Alpdundar; Kocabas, Banu Bayyurt; Yazar, Volkan; Aykut, Gamze; Guler, Ulku; Salih, Bekir; Yilmaz, Naz Surucu; Ayanoglu, Ihsan Cihan; Polat, Muammer Merve; Akcali, Kamil Can; Gursel, Ihsan; Gursel, Mayda

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{
  "@context": "https://schema.org/", 
  "@id": 5883, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
      "name": "Bulut, Esin Alpdundar"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ihsan Dogramaci Bilkent Univ, Dept Mol Biol & Genet, Therapeut Oligodeoxynucleotide Res Lab, TR-06800 Ankara, Turkey", 
      "name": "Kocabas, Banu Bayyurt"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ihsan Dogramaci Bilkent Univ, Dept Mol Biol & Genet, Therapeut Oligodeoxynucleotide Res Lab, TR-06800 Ankara, Turkey", 
      "name": "Yazar, Volkan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ihsan Dogramaci Bilkent Univ, Dept Mol Biol & Genet, Therapeut Oligodeoxynucleotide Res Lab, TR-06800 Ankara, Turkey", 
      "name": "Aykut, Gamze"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Guler, Ulku"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Chem, TR-06800 Ankara, Turkey", 
      "name": "Salih, Bekir"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
      "name": "Yilmaz, Naz Surucu"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
      "name": "Ayanoglu, Ihsan Cihan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Yuksek Ihtisas Univ, Fac Med, Dept Med Genet, TR-06520 Ankara, Turkey", 
      "name": "Polat, Muammer Merve"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ankara Univ, Fac Med, Dept Biophys, TR-06100 Ankara, Turkey", 
      "name": "Akcali, Kamil Can"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ihsan Dogramaci Bilkent Univ, Dept Mol Biol & Genet, Therapeut Oligodeoxynucleotide Res Lab, TR-06800 Ankara, Turkey", 
      "name": "Gursel, Ihsan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Middle East Tech Univ, Dept Biol Sci, TR-06800 Ankara, Turkey", 
      "name": "Gursel, Mayda"
    }
  ], 
  "datePublished": "2020-01-01", 
  "description": "Immunomodulatory commensal bacteria modify host immunity through delivery of regulatory microbial-derived products to host cells. Extracellular membrane vesicles (MVs) secreted from symbiont commensals represent one such transport mechanism. How MVs exert their anti-inflammatory effects or whether their tolerance-inducing potential can be used for therapeutic purposes remains poorly defined. In this study, we show that MVs isolated from the human lactic acid commensal bacteria Pediococcus pentosaceus suppressed Ag-specific humoral and cellular responses. MV treatment of bone marrow-derived macrophages and bone marrow progenitors promoted M2-like macrophage polarization and myeloid-derived suppressor cell differentiation, respectively, most likely in a TLR2-dependent manner. Consistent with their immunomodulatory activity, MV-differentiated cells upregulated expression of IL-10, arginase-1, and PD-L1 and suppressed the proliferation of activated T cells. MVs' antiinflammatory effects were further tested in acute inflammation models in mice. In carbon tetrachloride-induced fibrosis and zymosan-induced peritonitis models, MVs ameliorated inflammation. In the dextran sodium sulfate-induced acute colitis model, systemic treatment with MVs prevented colon shortening and loss of crypt architecture. In an excisional wound healing model, i.p. MV administration accelerated wound closure through recruitment of PD-L1-expressing myeloid cells to the wound site. Collectively, these results indicate that P pentosaceus-derived MVs hold promise as therapeutic agents in management/treatment of inflammatory conditions.", 
  "headline": "Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells", 
  "identifier": 5883, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Human Gut Commensal Membrane Vesicles Modulate Inflammation by Generating M2-like Macrophages and Myeloid-Derived Suppressor Cells", 
  "url": "https://aperta.ulakbim.gov.tr/record/5883"
}