1 Ocak 2016 Dergi makalesi Açık Erişim

Yaylaci, Seher Ustun; Sen, Merve; Bulut, Ozlem; Arslan, Elif; Guler, Mustafa O.; Tekinay, Ayse B.

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:zenodo.org:58751</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Glycosaminoglycans (GAGs) are important extracellular matrix components of cartilage tissue and provide biological signals to stem cells and chondrocytes for development and functional regeneration of cartilage. Among their many functions, particularly sulfated glycosaminoglycans bind to growth factors and enhance their functionality through enabling growth factor receptor interactions. Growth factor binding ability of the native sulfated glycosaminoglycans can be incorporated into the synthetic scaffold matrix through functionalization with specific chemical moieties. In this study, we used peptide amphiphile nanofibers functionalized with the chemical groups of native glycosaminoglycan molecules such as sulfonate, carboxylate and hydroxyl to induce the chondrogenic differentiation of rat mesenchymal stem cells (MSCs). The MSCs cultured on GAG-mimetic peptide nanofibers formed cartilage-like nodules and deposited cartilage-specific matrix components by day 7, suggesting that the GAG-mimetic peptide nanofibers effectively facilitated their commitment into the chondrogenic lineage. Interestingly, the chondrogenic differentiation degree was manipulated with the sulfonation degree of the nanofiber system. The GAG-mimetic peptide nanofibers network presented here serve as a tailorable bioactive and bioinductive platform for stem-cell-based cartilage regeneration studies.</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Yaylaci, Seher Ustun</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:1e28583b36015ba6cf750a9a97be268e</subfield>
    <subfield code="s">235</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/58751/files/bib-ae937a2f-561d-479f-9015-de9e9a2a81bb.txt</subfield>
  </datafield>
  <controlfield tag="005">20210316003541.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2016-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1021/acsbiomaterials.6b00099</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Chondrogenic Differentiation of Mesenchymal Stem Cells on Glycosaminoglycan-Mimetic Peptide Nanofibers</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">2</subfield>
    <subfield code="p">ACS BIOMATERIALS SCIENCE &amp; ENGINEERING</subfield>
    <subfield code="c">871-878</subfield>
    <subfield code="n">5</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Sen, Merve</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bulut, Ozlem</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Arslan, Elif</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Guler, Mustafa O.</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Tekinay, Ayse B.</subfield>
    <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</subfield>
  </datafield>
  <controlfield tag="001">58751</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>