1 Ocak 2016 Dergi makalesi Açık Erişim

Yaylaci, Seher Ustun; Ekiz, Melis Sardan; Arslan, Elif; Can, Nuray; Kilic, Erden; Ozkan, Huseyin; Orujalipoor, Ilghar; Ide, Semra; Tekinay, Ayse B.; Guler, Mustafa O.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/58031</identifier>
  <creators>
    <creator>
      <creatorName>Yaylaci, Seher Ustun</creatorName>
      <givenName>Seher Ustun</givenName>
      <familyName>Yaylaci</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr, UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ekiz, Melis Sardan</creatorName>
      <givenName>Melis Sardan</givenName>
      <familyName>Ekiz</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr, UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Arslan, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Arslan</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr, UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Can, Nuray</creatorName>
      <givenName>Nuray</givenName>
      <familyName>Can</familyName>
      <affiliation>Gulhane Mil Med Acad, Dept Orthopaed &amp; Traumatol, TR-06010 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kilic, Erden</creatorName>
      <givenName>Erden</givenName>
      <familyName>Kilic</familyName>
      <affiliation>Yuzuncuyil Hosp, TR-06530 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkan, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Gulhane Mil Med Acad, Dept Orthopaed &amp; Traumatol, TR-06010 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Orujalipoor, Ilghar</creatorName>
      <givenName>Ilghar</givenName>
      <familyName>Orujalipoor</familyName>
    </creator>
    <creator>
      <creatorName>Ide, Semra</creatorName>
      <givenName>Semra</givenName>
      <familyName>Ide</familyName>
    </creator>
    <creator>
      <creatorName>Tekinay, Ayse B.</creatorName>
      <givenName>Ayse B.</givenName>
      <familyName>Tekinay</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr, UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Mustafa O.</creatorName>
      <givenName>Mustafa O.</givenName>
      <familyName>Guler</familyName>
      <affiliation>Bilkent Univ, Natl Nanotechnol Res Ctr, UNAM, Inst Mat Sci &amp; Nanotechnol, TR-06800 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Supramolecular Gag-Like Self-Assembled Glycopeptide Nanofibers Induce Chondrogenesis And Cartilage Regeneration</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/58031</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acs.biomac.5b01669</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Glycosaminoglycans (GAGs) and glycoproteins are vital components of the extracellular matrix, directing cell proliferation, differentiation, and migration and tissue homeostasis. Here, we demonstrate supramolecular GAG-like glycopeptide nanofibers mimicking bioactive functions of natural hyaluronic acid molecules. Self-assembly of the glycopeptide amphiphile molecules enable organization of glucose residues in close proximity on a nanoscale structure forming a supramolecular GAG-like system. Our in vitro culture results indicated that the glycopeptide nanofibers are recognized through CD44 receptors, and promote chondrogenic differentiation of mesenchymal stem cells. We analyzed the bioactivity of GAG-like glycopeptide nanofibers in chondrogenic differentiation and injury models because hyaluronic acid is a major component of articular cartilage. Capacity of glycopeptide nanofibers on in vivo cartilage regeneration was demonstrated in microfracture treated osteochondral defect healing. The glycopeptide nanofibers act as a cell-instructive synthetic counterpart of hyaluronic acid, and they can be used in stem cell-based cartilage regeneration therapies.</description>
  </descriptions>
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