1 Ocak 2016 Dergi makalesi Açık Erişim

Golcu, Aysegul; Muslu, Harun; Kilicaslan, Derya; Cesme, Mustafa; Eren, Ozge; Atas, Fatma; Demirtas, Ibrahim

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        "affiliation": "Kahramanmaras Sutcu Imam Univ, Dept Chem, TR-46100 Kahramanmaras, Turkey", 
        "name": "Golcu, Aysegul"
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      {
        "affiliation": "Kahramanmaras Sutcu Imam Univ, Afsin Vocat High Sch, TR-46500 Kahramanmaras, Turkey", 
        "name": "Muslu, Harun"
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      {
        "affiliation": "Kahramanmaras Sutcu Imam Univ, Afsin Vocat High Sch, TR-46500 Kahramanmaras, Turkey", 
        "name": "Kilicaslan, Derya"
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      {
        "affiliation": "Kahramanmaras Sutcu Imam Univ, Dept Chem, TR-46100 Kahramanmaras, Turkey", 
        "name": "Cesme, Mustafa"
      }, 
      {
        "affiliation": "Kahramanmaras Sutcu Imam Univ, Dept Chem, TR-46100 Kahramanmaras, Turkey", 
        "name": "Eren, Ozge"
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      {
        "affiliation": "Kahramanmaras Sutcu Imam Univ, Dept Chem, TR-46100 Kahramanmaras, Turkey", 
        "name": "Atas, Fatma"
      }, 
      {
        "affiliation": "Cankiri Karatekin Univ, Dept Chem, TR-18100 Cankiri, Turkey", 
        "name": "Demirtas, Ibrahim"
      }
    ], 
    "description": "The new generation drug candidate molecules [Cu(5-Fu)(2)Cl2H2O] (NGDCMI) and [Zn(5-Fu)(2)(CH3COO)(2)] (NGDCM2) were obtained from the reaction of copper(II) and zinc(II) salts with the anticancer drug 5-fluoracil (5-Fu). These compounds have been characterized by spectroscopic and analytical techniques. Thermal behavior of the compounds were also investigated. The electrochemical properties of the compounds have been investigated by cyclic voltammetry (CV) using glassy carbon electrode. The biological activity of the NGDCMI and NGDCM2 has been evaluated by examining their ability to bind to fish sperm double strand DNA (FSdsDNA) with UV spectroscopy. UV studies of the interaction of the 5-Fu and metal derivatives with FSdsDNA have shown that these compounds can bind to FSdsDNA. The binding constants of the compounds with FSdsDNA have also been calculated. Thermal decomposition of the compounds lead to the formation of CuO and ZnO as final products.", 
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    "journal": {
      "pages": "96-109", 
      "title": "JOURNAL OF MOLECULAR STRUCTURE", 
      "volume": "1119"
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      "title": "Dergi makalesi", 
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    "title": "The new generation drug candidate molecules: Spectral, electrochemical, DNA-binding and anticancer activity properties"
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