1 Ocak 2016 Dergi makalesi Açık Erişim

Irtegun, Sevgi; Pektanc, Gulsum; Akkurt, Zeynep M.; Bozkurt, Mehtap; Turkcu, Fatih M.; Kalkanli-Tas, Sevgi

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/57303</identifier>
  <creators>
    <creator>
      <creatorName>Irtegun, Sevgi</creatorName>
      <givenName>Sevgi</givenName>
      <familyName>Irtegun</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Med Biol, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Pektanc, Gulsum</creatorName>
      <givenName>Gulsum</givenName>
      <familyName>Pektanc</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Med Biol, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akkurt, Zeynep M.</creatorName>
      <givenName>Zeynep M.</givenName>
      <familyName>Akkurt</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Dermatol, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozkurt, Mehtap</creatorName>
      <givenName>Mehtap</givenName>
      <familyName>Bozkurt</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Phys Therapy &amp; Rehabil, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turkcu, Fatih M.</creatorName>
      <givenName>Fatih M.</givenName>
      <familyName>Turkcu</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Ophthalmol, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kalkanli-Tas, Sevgi</creatorName>
      <givenName>Sevgi</givenName>
      <familyName>Kalkanli-Tas</familyName>
      <affiliation>Dicle Univ, Fac Med, Dept Immunol, TR-21280 Diyarbakir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Pharmacological Inactivation Of Src Family Kinases Inhibits Lps-Induced Tnf-Alpha Production In Pbmc Of Patients With Behcet'S Disease</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/57303</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1155/2016/5414369</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Behcet's disease (BD) is a multisystemic chronic inflammatory disease characterized by relapsing oral and genital ulcers, uveitis, and skin lesions. The pathogenesis of BD is still unknown. Aberrant production of some cytokines/chemokines plays an important role in the pathogenesis of various inflammatory diseases. Revealing a key signaling regulatory mechanism involved in proinflammatory cytokines/chemokines production is critical for understanding of the pathogenesis of BD. The aim of this study was to determine the role of Src family kinases (SFKs) in production of some LPS-induced proinflammatory cytokines/chemokines in peripheral blood mononuclear cells (PBMC) of active BD patients. Chemical inhibition of SFKs activity impaired LPS-induced TNF-alpha production in PBMC of active BD patients, suggesting that modulating SFKs activity may be a potential target for BD treatment.</description>
  </descriptions>
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