1 Ocak 2016 Dergi makalesi Açık Erişim

Erdogan, Hakan; Yilmaz, Mehmet; Babur, Esra; Duman, Memed; Aydin, Halil M.; Demirel, Gokhan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/57253</identifier>
  <creators>
    <creator>
      <creatorName>Erdogan, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Erdogan</familyName>
      <affiliation>Gazi Univ, Dept Chem, Bioinspired Mat Res Lab BIMREL, TR-06500 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Mehmet</creatorName>
      <givenName>Mehmet</givenName>
      <familyName>Yilmaz</familyName>
    </creator>
    <creator>
      <creatorName>Babur, Esra</creatorName>
      <givenName>Esra</givenName>
      <familyName>Babur</familyName>
      <affiliation>Gazi Univ, Dept Chem, Bioinspired Mat Res Lab BIMREL, TR-06500 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Duman, Memed</creatorName>
      <givenName>Memed</givenName>
      <familyName>Duman</familyName>
      <affiliation>Hacettepe Univ, Inst Grad Studies Sci &amp; Engn, Dept Nanotechnol &amp; Nanomed, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aydin, Halil M.</creatorName>
      <givenName>Halil M.</givenName>
      <familyName>Aydin</familyName>
    </creator>
    <creator>
      <creatorName>Demirel, Gokhan</creatorName>
      <givenName>Gokhan</givenName>
      <familyName>Demirel</familyName>
      <affiliation>Gazi Univ, Dept Chem, Bioinspired Mat Res Lab BIMREL, TR-06500 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Fabrication Of Plasmonic Nanorod-Embedded Dipeptide Microspheres Via The Freeze-Quenching Method For Near-Infrared Laser-Triggered Drug-Delivery Applications</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/57253</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acs.biomac.6b00214</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Control of drug release by an external stimulus may provide remote controllability, low toxicity, and reduced side effects. In this context, varying physical external stimuli, including magnetic and electric fields, ultrasound, light, and pharmacological stimuli, have been employed to control the release rate of drug molecules in a diseased region. However, the design and development of alternative on-demand drug-delivery systems that permit control of the dosage of drug released via an external stimulus are still required. Here, we developed near-infrared laser-activatable microspheres based on Fmoc-diphenylalanine (Phe-Phe) dipeptides and plasmonic gold nanorods (AuNRs) via a simple freeze-quenching approach. These plasmonic nanoparticle-embedded microspheres were then employed as a smart drug-delivery platform for native, continuous, and pulsatile doxorubicin (DOX) release. Remarkable sustained, burst, and on-demand DOX release from the fabricated microspheres were achieved by manipulating the laser exposure time. Our results demonstrate that AuNR-embedded dipeptide microspheres have great potential for controlled drug delivery systems.</description>
  </descriptions>
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