1 Ocak 2016 Dergi makalesi Açık Erişim

Dogan, Inci S.; Ozel, Arzu; Birinci, Zeynep; Barut, Burak; Sellitepe, Hasan E.; Kahveci, Bahittin

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/56603</identifier>
  <creators>
    <creator>
      <creatorName>Dogan, Inci S.</creatorName>
      <givenName>Inci S.</givenName>
      <familyName>Dogan</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Pharmaceut Chem, TR-61080 Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozel, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Ozel</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Biochem, Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Birinci, Zeynep</creatorName>
      <givenName>Zeynep</givenName>
      <familyName>Birinci</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Pharmaceut Chem, TR-61080 Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Barut, Burak</creatorName>
      <givenName>Burak</givenName>
      <familyName>Barut</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Biochem, Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sellitepe, Hasan E.</creatorName>
      <givenName>Hasan E.</givenName>
      <familyName>Sellitepe</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Pharm, Dept Pharmaceut Chem, TR-61080 Trabzon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kahveci, Bahittin</creatorName>
      <givenName>Bahittin</givenName>
      <familyName>Kahveci</familyName>
      <affiliation>Karadeniz Tech Univ, Fac Hlth Sci, Dept Nutr &amp; Dietet, Trabzon, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis Of Some Novel 2-Substitutedbenzyl-(4)7-Phenyl-1H-Benzo[D]Imidazoles In Mild Conditions As Potent Anti-Tyrosinase And Antioxidant Agents</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/56603</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1002/ardp.201600224</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Novel 2-substitutedbenzyl-4(7)-phenyl-1H-benzo[d]imidazole compounds were synthesized and characterized. Although 2a and 2b were reported previously in the literature, 11 compounds were synthesized (nine of them were newly synthesized) and the tyrosinase inhibitory effects and antioxidant activities of these compounds were studied for the first time. All of the synthesized compounds displayed certain inhibitory effects on tyrosinase, with IC50 values ranging from 37.86 +/- 0.24 to 75.81 +/- 2.49 mu M. Among the compounds, 2j exhibited similar tyrosinase inhibitory effect (IC50 +/- 37.86 +/- 0.24 mu M) to the positive control, kojic acid (IC50 +/- 21.93 +/- 0.11 mu M). Kinetic studies revealed it to act as non-competitive tyrosinase inhibitor with a K-i value of 50.2 mu M. The antioxidant activities of the compounds were investigated by using in vitro antioxidant assays, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP). All of these results indicated that the compounds might have potential application as tyrosinase inhibitors.</description>
  </descriptions>
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