1 Ocak 2016 Dergi makalesi Açık Erişim

Eroglu, Ipek; Azizoglu, Erkan; Ozyazici, Mine; Nenni, Merve; Orhan, Hande Gurer; Ozbal, Seda; Tekmen, Isil; Ertam, Ilgen; Unal, Idil; Ozer, Ozgen

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/56187</identifier>
  <creators>
    <creator>
      <creatorName>Eroglu, Ipek</creatorName>
      <givenName>Ipek</givenName>
      <familyName>Eroglu</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Azizoglu, Erkan</creatorName>
      <givenName>Erkan</givenName>
      <familyName>Azizoglu</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozyazici, Mine</creatorName>
      <givenName>Mine</givenName>
      <familyName>Ozyazici</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nenni, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Nenni</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Toxicol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Orhan, Hande Gurer</creatorName>
      <givenName>Hande Gurer</givenName>
      <familyName>Orhan</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Toxicol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozbal, Seda</creatorName>
      <givenName>Seda</givenName>
      <familyName>Ozbal</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Med, Dept Histol &amp; Embryol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekmen, Isil</creatorName>
      <givenName>Isil</givenName>
      <familyName>Tekmen</familyName>
      <affiliation>Dokuz Eylul Univ, Fac Med, Dept Histol &amp; Embryol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ertam, Ilgen</creatorName>
      <givenName>Ilgen</givenName>
      <familyName>Ertam</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Dermatol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Unal, Idil</creatorName>
      <givenName>Idil</givenName>
      <familyName>Unal</familyName>
      <affiliation>Ege Univ, Fac Med, Dept Dermatol, Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozer, Ozgen</creatorName>
      <givenName>Ozgen</givenName>
      <familyName>Ozer</familyName>
      <affiliation>Ege Univ, Fac Pharm, Dept Pharmaceut Technol, TR-35100 Izmir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Effective Topical Delivery Systems For Corticosteroids: Dermatological And Histological Evaluations</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/56187</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.3109/10717544.2014.960981</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Atopic dermatitis (AD) is a chronic and relapsing skin disease with severe eczematous lesions. Long-term topical corticosteroid treatment can induce skin atrophy, hypopigmentation and transepidermal water loss (TEWL) increase. A new treatment approach was needed to reduce the risk by dermal targeting. For this purpose, Betamethasone valerate (BMV)/Diflucortolone valerate (DFV)-loaded liposomes (220-350 nm) were prepared and incorporated into chitosan gel to obtain adequate viscosity (similar to 13 000 cps). Drugs were localized in stratum corneum + epidermis of rat skin in ex-vivo permeation studies. The toxicity was assessed on human fibroblast cells. In point of in-vivo studies, pharmacodynamic responses, treatment efficacy and skin irritation were evaluated and compared with previously prepared nanoparticles. Liposome/nanoparticle in gel formulations produced higher paw edema inhibition in rats with respect to the commercial cream. Similar skin blanching effect with commercial creams was obtained via liposome in gels although they contain 10 times less drug. Dermatological scoring results, prognostic histological parameters and suppression of mast cell numbers showed higher treatment efficiency of liposome/nanoparticle in gel formulations in AD-induced rats. TEWL and erythema measurements confirmed these results. Overview of obtained results showed that liposomes might be an effective and safe carrier for corticosteroids in skin disease treatment.</description>
  </descriptions>
</resource>