1 Ocak 2016 Dergi makalesi Açık Erişim

Canpolat, Sinan; Ulker, Nazife; Yardimci, Ahmet; Bulmus, Ozgur; Ozdemir, Gokcen; Sahin, Zafer; Ercan, Zubeyde; Serhatlioglu, Ihsan; Kacar, Emine; Ozcan, Mete; Turk, Gaffari; Ozkan, Yusuf; Atmaca, Murad; Yilmaz, Bayram; Kelestimur, Haluk

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/55509</identifier>
  <creators>
    <creator>
      <creatorName>Canpolat, Sinan</creatorName>
      <givenName>Sinan</givenName>
      <familyName>Canpolat</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ulker, Nazife</creatorName>
      <givenName>Nazife</givenName>
      <familyName>Ulker</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yardimci, Ahmet</creatorName>
      <givenName>Ahmet</givenName>
      <familyName>Yardimci</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bulmus, Ozgur</creatorName>
      <givenName>Ozgur</givenName>
      <familyName>Bulmus</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozdemir, Gokcen</creatorName>
      <givenName>Gokcen</givenName>
      <familyName>Ozdemir</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sahin, Zafer</creatorName>
      <givenName>Zafer</givenName>
      <familyName>Sahin</familyName>
      <affiliation>Necmettin Erbakan Univ, Fac Hlth Sci, Dept Physiotherapy &amp; Rehabil, Konya, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ercan, Zubeyde</creatorName>
      <givenName>Zubeyde</givenName>
      <familyName>Ercan</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Serhatlioglu, Ihsan</creatorName>
      <givenName>Ihsan</givenName>
      <familyName>Serhatlioglu</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Biophys, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kacar, Emine</creatorName>
      <givenName>Emine</givenName>
      <familyName>Kacar</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozcan, Mete</creatorName>
      <givenName>Mete</givenName>
      <familyName>Ozcan</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Biophys, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Turk, Gaffari</creatorName>
      <givenName>Gaffari</givenName>
      <familyName>Turk</familyName>
      <affiliation>Firat Univ, Fac Vet Med, Dept Reprod &amp; Artificial Inseminat, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozkan, Yusuf</creatorName>
      <givenName>Yusuf</givenName>
      <familyName>Ozkan</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Endocrinol &amp; Metab, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Atmaca, Murad</creatorName>
      <givenName>Murad</givenName>
      <familyName>Atmaca</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Psychiat, TR-23169 Elazig, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaz, Bayram</creatorName>
      <givenName>Bayram</givenName>
      <familyName>Yilmaz</familyName>
      <affiliation>Yeditepe Univ, Sch Med, Dept Physiol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kelestimur, Haluk</creatorName>
      <givenName>Haluk</givenName>
      <familyName>Kelestimur</familyName>
      <affiliation>Firat Univ, Sch Med, Dept Physiol, TR-23169 Elazig, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Studies On The Reproductive Effects Of Chronic Treatment With Agomelatine In The Rat</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/55509</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejphar.2015.11.054</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Agomelatine is an antidepressant with a novel mechanism of action. It is a melatonergic agonist for MT1 and MT2 receptors and a serotonin (5-HT2C) receptor antagonist. Agomelatine has been suggested not to have adverse effects on sexual functions. However, the effects of chronic agomelatine administration on reproductive functions have not been sufficiently studied in animal models. We mainly aimed to explore the effects of agomelatine on reproductive functions in the male and female rats. For the experimental studies, Sprague Dawley rats were used. The animals started to receive daily oral agomelatine (10 mg/kg) on post-natal day 21. Agomelatine advanced vaginal opening in the female rats whereas it delayed puberty onset in the male rats. Agomelatine treatment significantly decreased intromission frequencies, which indicates a facilitator role of this antidepressant on male sexual behavior. In the forced swimming test (FST) used for assessing antidepressant efficacy, agomelatine induced a significant decrease in duration of immobility, and an increase in the swimming time, respectively, which confirms the antidepressant-like activity of agomelatine. The present findings suggest that agomelatine shows a strong antidepressant effect in the male rats without any adverse influences on sexual behavior, and its effects on pubertal maturation seem to show sex-dependent differences. (C) 2015 Elsevier B.V. All rights reserved.</description>
  </descriptions>
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