Dergi makalesi Açık Erişim
Taskin, Turgut; Ozakpinar, Ozlem B.; Gurbuz, Burcak; Uras, Fikriye; Gurer, Umran S.; Bitis, Leyla
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Identification of phenolic compounds and evaluation of antioxidant, antimicrobial and cytotoxic effects of the endemic Achillea multifida</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">INDIAN JOURNAL OF TRADITIONAL KNOWLEDGE</subfield> <subfield code="v">15</subfield> <subfield code="n">4</subfield> <subfield code="c">594-603</subfield> </datafield> <controlfield tag="001">54499</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">The aim of this study was to evaluate for the first time total phenolic content, antioxidant, antimicrobial and cytotoxic effects of heptane, chloroform and methanol extracts from Achillea multifida (DC.) Boiss. (Compositae) aerial parts followed by identification of phenolic compounds in the methanol extract, which showed the highest total amount of phenolics, antioxidant and antibacterial activity. The phenolic compounds in methanol extract were identified for the first time by ESI-Q-TOF LC/MS. The phenolic compounds were identified as: chlorogenic acid; quercetin hexoside; luteolin-7-O glucoside; dicaffeoyl quinic acid; luteolin. The chloroform extract showed strong activity and selectivity against HeLa, HT-29 and MCF-7 cell lines. The results indicated that low concentrations (100 mu g/mL and 50 mu g/mL) of chloroform and methanol extracts had no toxic effects on the NIH/3T3 cells. Therefore, the methanol extract from A. multifida aerial parts may be a natural source of antioxidants and antibacterial and seems to have potential application in both medicine and the food industry. In additon, the chloroform extract might be a potential anti-cancer agent.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Biochem, Fac Pharm, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Ozakpinar, Ozlem B.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Pharmaceut Microbiol, Fac Pharm, Istanbul, Turkey</subfield> <subfield code="a">Gurbuz, Burcak</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Biochem, Fac Pharm, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Uras, Fikriye</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Pharmaceut Microbiol, Fac Pharm, Istanbul, Turkey</subfield> <subfield code="a">Gurer, Umran S.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Pharmacognosy, Fac Pharm, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Bitis, Leyla</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Marmara Univ, Dept Pharmacognosy, Fac Pharm, TR-34668 Istanbul, Turkey</subfield> <subfield code="a">Taskin, Turgut</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2016-01-01</subfield> </datafield> <controlfield tag="005">20210315233814.0</controlfield> <datafield tag="773" ind1=" " ind2=" "> <subfield code="n">doi</subfield> <subfield code="a">10.81043/aperta.54498</subfield> <subfield code="i">isVersionOf</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:54499</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:da054e6331aee2e43080c68977ff13a0</subfield> <subfield code="s">274</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/54499/files/bib-77c0bf91-8aea-4ca9-9f93-c155299f978d.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.81043/aperta.54499</subfield> <subfield code="2">doi</subfield> </datafield> </record>
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