1 Ocak 2016 Dergi makalesi Açık Erişim

Young, Jonathon; Schafer, Christian; Solan, Agnes; Baldrica, Anthony; Belcher, Miranda; Nisanci, Bilal; Wheeler, Kraig A.; Trivedi, Evan R.; Torok, Bela; Dembinski, Roman

JSON

{
  "conceptrecid": "53938", 
  "created": "2021-03-15T23:30:10.423269+00:00", 
  "doi": "10.1039/c6ra24291j", 
  "files": [
    {
      "bucket": "8476141c-1c1c-4565-9c23-19d47d875030", 
      "checksum": "md5:b6b7081f23f09d0b1e58f08d3a057189", 
      "key": "bib-357f4ae3-9102-4f86-ab5e-28c70aa60734.txt", 
      "links": {
        "self": "https://aperta.ulakbim.gov.tr/api/files/8476141c-1c1c-4565-9c23-19d47d875030/bib-357f4ae3-9102-4f86-ab5e-28c70aa60734.txt"
      }, 
      "size": 348, 
      "type": "txt"
    }
  ], 
  "id": 53939, 
  "links": {
    "badge": "https://aperta.ulakbim.gov.tr/badge/doi/10.1039/c6ra24291j.svg", 
    "bucket": "https://aperta.ulakbim.gov.tr/api/files/8476141c-1c1c-4565-9c23-19d47d875030", 
    "doi": "https://doi.org/10.1039/c6ra24291j", 
    "html": "https://aperta.ulakbim.gov.tr/record/53939", 
    "latest": "https://aperta.ulakbim.gov.tr/api/records/53939", 
    "latest_html": "https://aperta.ulakbim.gov.tr/record/53939"
  }, 
  "metadata": {
    "access_right": "open", 
    "access_right_category": "success", 
    "communities": [
      {
        "id": "tubitak-destekli-proje-yayinlari"
      }
    ], 
    "creators": [
      {
        "affiliation": "Oakland Univ, Dept Chem, 146 Lib Dr, Rochester, MI 48309 USA", 
        "name": "Young, Jonathon"
      }, 
      {
        "affiliation": "Univ Massachusetts, Dept Chem, 100 Morrissey Blvd, Boston, MA 02125 USA", 
        "name": "Schafer, Christian"
      }, 
      {
        "affiliation": "Oakland Univ, Dept Chem, 146 Lib Dr, Rochester, MI 48309 USA", 
        "name": "Solan, Agnes"
      }, 
      {
        "affiliation": "Oakland Univ, Dept Chem, 146 Lib Dr, Rochester, MI 48309 USA", 
        "name": "Baldrica, Anthony"
      }, 
      {
        "affiliation": "Oakland Univ, Dept Chem, 146 Lib Dr, Rochester, MI 48309 USA", 
        "name": "Belcher, Miranda"
      }, 
      {
        "name": "Nisanci, Bilal"
      }, 
      {
        "affiliation": "Eastern Illinois Univ, Dept Chem, 600 Lincoln Ave, Charleston, IL 61920 USA", 
        "name": "Wheeler, Kraig A."
      }, 
      {
        "affiliation": "Oakland Univ, Dept Chem, 146 Lib Dr, Rochester, MI 48309 USA", 
        "name": "Trivedi, Evan R."
      }, 
      {
        "affiliation": "Univ Massachusetts, Dept Chem, 100 Morrissey Blvd, Boston, MA 02125 USA", 
        "name": "Torok, Bela"
      }, 
      {
        "name": "Dembinski, Roman"
      }
    ], 
    "description": "The reaction of alk-3-yn-1-ones (a bifunctional reagent) with o-phenylenediamines provides an effective synthetic method with high atom economy for the preparation of diversely substituted 1,5-3H-benzodiazepines. The reaction initially leads to the formation of conjugated enaminones (3-amino-2alkenones, 51-99%), at room temperature, which constitutes a formal non-catalyzed hydroamination of the non-conjugated alkyne. Non-symmetrical o-phenylenediamines react in a regioselective fashion with respect to amino groups. Both the direct microwave-accelerated reaction of o-phenylenediamines with alkynones in ethanol and the intramolecular cyclization of intermediate enaminones in ethanol/acetic acid lead to substituted 1,5-benzodiazepines with good yields (39-92 and 26-99%). The regio-and stereochemical outcomes of these processes are confirmed by the X-ray structure determination of (Z)-3-[(2-amino-4-methylanilino)-4-(4-methylphenyl)-1-phenylbut-2-en-1-one],4-[(4-methylphenyl) methyl]-7-nitro-2-phenyl-3H-1,5-benzodiazepine and 6,8-dimethyl-4-(4-methylbenzyl)-2-phenyl-3Hbenzo[b][1,5]diazepine.", 
    "doi": "10.1039/c6ra24291j", 
    "has_grant": false, 
    "journal": {
      "issue": "108", 
      "pages": "107081-107093", 
      "title": "RSC ADVANCES", 
      "volume": "6"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2016-01-01", 
    "relations": {
      "version": [
        {
          "count": 1, 
          "index": 0, 
          "is_last": true, 
          "last_child": {
            "pid_type": "recid", 
            "pid_value": "53939"
          }, 
          "parent": {
            "pid_type": "recid", 
            "pid_value": "53938"
          }
        }
      ]
    }, 
    "resource_type": {
      "subtype": "article", 
      "title": "Dergi makalesi", 
      "type": "publication"
    }, 
    "title": "Regioselective \"hydroamination\" of alk-3-ynones with non-symmetrical o-phenylenediamines. Synthesis of diversely substituted 3H-1,5-benzodiazepines via (Z)-3-amino-2-alkenones"
  }, 
  "owners": [
    1
  ], 
  "revision": 1, 
  "stats": {
    "downloads": 5.0, 
    "unique_downloads": 5.0, 
    "unique_views": 24.0, 
    "version_downloads": 5.0, 
    "version_unique_downloads": 5.0, 
    "version_unique_views": 24.0, 
    "version_views": 26.0, 
    "version_volume": 1740.0, 
    "views": 26.0, 
    "volume": 1740.0
  }, 
  "updated": "2021-03-15T23:30:10.465913+00:00"
}