1 Ocak 2016 Dergi makalesi Açık Erişim

Yilmaz, Tulay; Guler, Emine; Gumus, Z. Pinar; Akbulut, Huseyin; Aldemir, Ebru; Coskunol, Hakan; Colak, Demet Goen; Cianga, Ioan; Yamada, Shuhei; Timur, Suna; Endo, Takeshi; Yagci, Yusuf

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/53757</identifier>
  <creators>
    <creator>
      <creatorName>Yilmaz, Tulay</creatorName>
      <givenName>Tulay</givenName>
      <familyName>Yilmaz</familyName>
    </creator>
    <creator>
      <creatorName>Guler, Emine</creatorName>
      <givenName>Emine</givenName>
      <familyName>Guler</familyName>
    </creator>
    <creator>
      <creatorName>Gumus, Z. Pinar</creatorName>
      <givenName>Z. Pinar</givenName>
      <familyName>Gumus</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akbulut, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Akbulut</familyName>
      <affiliation>Istanbul Tech Univ, Dept Chem, Fac Sci &amp; Letters, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aldemir, Ebru</creatorName>
      <givenName>Ebru</givenName>
      <familyName>Aldemir</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Coskunol, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Coskunol</familyName>
      <affiliation>Ege Univ, Inst Drug Abuse Toxicol &amp; Pharmaceut Sci, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Colak, Demet Goen</creatorName>
      <givenName>Demet Goen</givenName>
      <familyName>Colak</familyName>
      <affiliation>Istanbul Tech Univ, Dept Chem, Fac Sci &amp; Letters, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cianga, Ioan</creatorName>
      <givenName>Ioan</givenName>
      <familyName>Cianga</familyName>
    </creator>
    <creator>
      <creatorName>Yamada, Shuhei</creatorName>
      <givenName>Shuhei</givenName>
      <familyName>Yamada</familyName>
      <affiliation>Kinki Univ, Mol Engn Inst, 11-6 Kayanomori, Iizuka, Fukuoka 8208555, Japan</affiliation>
    </creator>
    <creator>
      <creatorName>Timur, Suna</creatorName>
      <givenName>Suna</givenName>
      <familyName>Timur</familyName>
    </creator>
    <creator>
      <creatorName>Endo, Takeshi</creatorName>
      <givenName>Takeshi</givenName>
      <familyName>Endo</familyName>
      <affiliation>Kinki Univ, Mol Engn Inst, 11-6 Kayanomori, Iizuka, Fukuoka 8208555, Japan</affiliation>
    </creator>
    <creator>
      <creatorName>Yagci, Yusuf</creatorName>
      <givenName>Yusuf</givenName>
      <familyName>Yagci</familyName>
      <affiliation>Istanbul Tech Univ, Dept Chem, Fac Sci &amp; Letters, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Synthesis And Application Of A Novel Poly-L-Phenylalanine Electroactive Macromonomer As Matrix For The Biosensing Of 'Abused Drug' Model</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/53757</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1039/c6py01764a</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Polypeptide-functionalized macromonomers are very fascinating candidates for the modification of various surfaces of different sizes as well as geometry, and have attracted considerable attention for biomolecule stabilization, biomedical device fabrication and bioanalytical applications. In the present work, synthesis and characterization of a novel poly-L-phenylalanine-bearing electroactive macromonomer (EDOT-BTDA-PPhe) were carried out. In the following steps, a glassy carbon electrode was covered with this material, and then cocaine aptamer was immobilized to obtain a biofunctional surface for the biosensing of ` Abused Drug' model. Aptamers attached to polypeptide side chains on the macromonomer with good orientation are induced for conformational change into three-way junction form as a result of selective binding of cocaine or its metabolite. This aptamer folding-based conformational response provides detectable signals due to formation of a compact interface which restricts electron transfer of redox probe. The stepwise modification of the surface was confirmed by electrochemical techniques. At the final step, the aptasensor was applied for the electrochemical detection of cocaine and its major metabolite, benzoylecgonine (BE), which exhibited a linear correlation between 1.0 and 10 nM and between 0.5 and 10 mu M respectively. The proposed methods were successfully employed for the analysis of synthetic biological fluids.</description>
  </descriptions>
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