Dergi makalesi Açık Erişim
Sever, Melike; Turkyilmaz, Mesut; Sevinc, Cansu; Cakir, Aysen; Ocalan, Busra; Cansev, Mehmet; Guler, Mustafa O.; Tekinay, Ayse B.
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Regenerative effects of peptide nanofibers in an experimental model of Parkinson's disease</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">ACTA BIOMATERIALIA</subfield> <subfield code="v">46</subfield> <subfield code="c">79-90</subfield> </datafield> <controlfield tag="001">53515</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">Parkinson's disease (PD) is characterized by progressive degeneration of dopaminergic nigrostriatal neurons and reduction in striatal dopamine levels. Although there are few treatment options for PD such as Levodopa, they are used just to relieve and modify the symptoms. There are no therapies available for PD to slow down the degeneration process in the brain and recover the lost function. In this study, we used extracellular matrix (ECM) mimetic peptide amphiphile (PA) nanofibers as a potential therapeutic approach in a PD rat model. We demonstrated the effect of heparan sulfate mimetic and laminin mimetic PA nanofibers on reducing striatal injury and enhancing functional recovery after unilateral striatal injection of 6-hydroxydopamine (6-OHDA). The bioactive self-assembled PA nanofibers significantly reduced forelimb asymmetry, contralateral forelimb akinesia and d-amphetamine-induced rotational behavior in cylinder, stepping and rotation tests, respectively, in 6-OHDA-lesioned rats after 6 weeks. The behavioral improvement with PA nanofiber administration was associated with enhanced striatal dopamine and tyrosine hydroxylase content as well as reduced cleaved-Caspase-3 levels. Histological assessment also showed that PA nanofiber injection to the striatum resulted in better tissue integrity compared to control groups. In addition, PA nanofibers reduced the progressive cell loss in SH-SYSY cells caused by 6-OHDA treatment. These data showed that the bioactive peptide nanofibers improve neurochemical and behavioral consequences of Parkinsonism in rats and provide a promising new strategy for treatment of PD.</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Uludag Univ, Dept Pharmacol, Sch Med, TR-16059 Bursa, Turkey</subfield> <subfield code="a">Turkyilmaz, Mesut</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Uludag Univ, Dept Pharmacol, Sch Med, TR-16059 Bursa, Turkey</subfield> <subfield code="a">Sevinc, Cansu</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Uludag Univ, Dept Physiol, Sch Med, TR-16059 Bursa, Turkey</subfield> <subfield code="a">Cakir, Aysen</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Uludag Univ, Dept Physiol, Sch Med, TR-16059 Bursa, Turkey</subfield> <subfield code="a">Ocalan, Busra</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Uludag Univ, Dept Pharmacol, Sch Med, TR-16059 Bursa, Turkey</subfield> <subfield code="a">Cansev, Mehmet</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</subfield> <subfield code="a">Guler, Mustafa O.</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</subfield> <subfield code="a">Tekinay, Ayse B.</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="b">article</subfield> <subfield code="a">publication</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="u">Bilkent Univ, Natl Nanotechnol Res Ctr UNAM, Inst Mat Sci & Nanotechnol, TR-06800 Ankara, Turkey</subfield> <subfield code="a">Sever, Melike</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2016-01-01</subfield> </datafield> <controlfield tag="005">20210315232437.0</controlfield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:53515</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="z">md5:c9f136eb062672a089afc83768ba2cff</subfield> <subfield code="s">234</subfield> <subfield code="u">https://aperta.ulakbim.gov.trrecord/53515/files/bib-52e47ca6-2d50-44fd-a875-66fc5c7b0b28.txt</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> <subfield code="a">Creative Commons Attribution</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1016/j.actbio.2016.09.011</subfield> <subfield code="2">doi</subfield> </datafield> </record>
Görüntülenme | 44 |
İndirme | 11 |
Veri hacmi | 2.6 kB |
Tekil görüntülenme | 40 |
Tekil indirme | 9 |