1 Ocak 2016 Dergi makalesi Açık Erişim

Avci, Hamdi; Sekkin, Selim; Boyacioglu, Murat; Aksit, Hasan; Tunca, Recai; Epikmen, E. Tugrul; Birincioglu, S. Serap

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/53293</identifier>
  <creators>
    <creator>
      <creatorName>Avci, Hamdi</creatorName>
      <givenName>Hamdi</givenName>
      <familyName>Avci</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pathol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sekkin, Selim</creatorName>
      <givenName>Selim</givenName>
      <familyName>Sekkin</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pharmacol &amp; Toxicol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Boyacioglu, Murat</creatorName>
      <givenName>Murat</givenName>
      <familyName>Boyacioglu</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pharmacol &amp; Toxicol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Aksit, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Aksit</familyName>
      <affiliation>Univ Balikesir, Dept Biochem, Fac Vet Med, TR-10100 Balikesir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tunca, Recai</creatorName>
      <givenName>Recai</givenName>
      <familyName>Tunca</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pathol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Epikmen, E. Tugrul</creatorName>
      <givenName>E. Tugrul</givenName>
      <familyName>Epikmen</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pathol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Birincioglu, S. Serap</creatorName>
      <givenName>S. Serap</givenName>
      <familyName>Birincioglu</familyName>
      <affiliation>Adnan Menderes Univ, Dept Pathol, Fac Vet Med, TR-09016 Aydin, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Protective And Antigenotoxic Effects Of Silymarin And Curcumin In Experimental Cyclophosphamide Intoxication In Rats</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2016</publicationYear>
  <dates>
    <date dateType="Issued">2016-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/53293</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.9775/kvfd.2016.15145</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">The aim of this study was to investigate the protective effects of silymarin (SLY) and curcumin (CUR), which have strong antioxidant properties, against the toxic effects of high dose of cyclophosphamide (CP) on the liver and kidneys of rats. For this purpose, a total of 36 adult Wistar albino female rats at the weight of, 250 +/- 10 g were used. Biochemical parameters were found to be significantly higher in the CP-only group than in the other groups. In the groups in which SLY and CUR were administered concurrently with CP, biochemical parameters were found to be significantly lower than in the CP-only group. In the SLY+CP and CUR+CP groups, biochemical parameters were correlated with the severity of histopathological findings. In genotoxic examination, the comet parameter levels in the SLY+CP and CUR+CP-treated groups were lower than those in the CP-treated group. The present study established that both SLY and CUR are effective against the toxic effects of high doses of CP.</description>
  </descriptions>
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