1 Ocak 2017 Dergi makalesi Açık Erişim

Tsatsakis, A. M.; Kouretas, D.; Tzatzarakis, M. N.; Stivaktakis, P.; Tsarouhas, K.; Golokhvast, K. S.; Rakitskii, V. N.; Tutelyan, V. A.; Hernandez, A. F.; Rezaee, R.; Chung, G.; Fenga, C.; Engin, A. B.; Neagu, M.; Arsene, A. L.; Docea, A. O.; Gofita, E.; Calina, D.; Taitzoglou, I.; Liesivuori, J.; Liesivuori, J.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/52521</identifier>
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    <creator>
      <creatorName>Tsatsakis, A. M.</creatorName>
      <givenName>A. M.</givenName>
      <familyName>Tsatsakis</familyName>
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    <creator>
      <creatorName>Kouretas, D.</creatorName>
      <givenName>D.</givenName>
      <familyName>Kouretas</familyName>
      <affiliation>Univ Thessaly, Dept Biochem &amp; Biotechnol, Larisa, Greece</affiliation>
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    <creator>
      <creatorName>Tzatzarakis, M. N.</creatorName>
      <givenName>M. N.</givenName>
      <familyName>Tzatzarakis</familyName>
      <affiliation>Univ Crete, Sch Med, Ctr Toxicol Sci &amp; Res, Iraklion 71003, Crete, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Stivaktakis, P.</creatorName>
      <givenName>P.</givenName>
      <familyName>Stivaktakis</familyName>
      <affiliation>Univ Crete, Sch Med, Ctr Toxicol Sci &amp; Res, Iraklion 71003, Crete, Greece</affiliation>
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    <creator>
      <creatorName>Tsarouhas, K.</creatorName>
      <givenName>K.</givenName>
      <familyName>Tsarouhas</familyName>
      <affiliation>Univ Hosp Larissa, Dept Cardiol, Larisa, Thessaly Prefec, Greece</affiliation>
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    <creator>
      <creatorName>Golokhvast, K. S.</creatorName>
      <givenName>K. S.</givenName>
      <familyName>Golokhvast</familyName>
      <affiliation>Far Eastern Fed Univ, Sci Educ Ctr Nanotechnol, Vladivostok, Russia</affiliation>
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    <creator>
      <creatorName>Rakitskii, V. N.</creatorName>
      <givenName>V. N.</givenName>
      <familyName>Rakitskii</familyName>
      <affiliation>FF Erisman, Fed Sci Ctr Hyg, Moscow, Russia</affiliation>
    </creator>
    <creator>
      <creatorName>Tutelyan, V. A.</creatorName>
      <givenName>V. A.</givenName>
      <familyName>Tutelyan</familyName>
      <affiliation>Fed Res Ctr Nutr Biotechnol &amp; Food Safety, Moscow, Russia</affiliation>
    </creator>
    <creator>
      <creatorName>Hernandez, A. F.</creatorName>
      <givenName>A. F.</givenName>
      <familyName>Hernandez</familyName>
      <affiliation>Univ Granada, Dept Legal Med &amp; Toxicol, Sch Med, Granada, Spain</affiliation>
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    <creator>
      <creatorName>Rezaee, R.</creatorName>
      <givenName>R.</givenName>
      <familyName>Rezaee</familyName>
      <affiliation>North Khorasan Univ Med Sci, Sch Med, Dept Physiol &amp; Pharmacol, Bojnurd, Iran</affiliation>
    </creator>
    <creator>
      <creatorName>Chung, G.</creatorName>
      <givenName>G.</givenName>
      <familyName>Chung</familyName>
      <affiliation>Chonnam Natl Univ, Dept Biotechnol, Yeosu, Chonnam, South Korea</affiliation>
    </creator>
    <creator>
      <creatorName>Fenga, C.</creatorName>
      <givenName>C.</givenName>
      <familyName>Fenga</familyName>
      <affiliation>Univ Messina, Dept Occupat Med, Messina, Italy</affiliation>
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    <creator>
      <creatorName>Engin, A. B.</creatorName>
      <givenName>A. B.</givenName>
      <familyName>Engin</familyName>
      <affiliation>Gazi Univ, Dept Toxicol, Fac Pharm, Ankara, Turkey</affiliation>
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    <creator>
      <creatorName>Neagu, M.</creatorName>
      <givenName>M.</givenName>
      <familyName>Neagu</familyName>
      <affiliation>Victor Babes Natl Inst Pathol, Dept Immunol, Bucharest, Romania</affiliation>
    </creator>
    <creator>
      <creatorName>Arsene, A. L.</creatorName>
      <givenName>A. L.</givenName>
      <familyName>Arsene</familyName>
      <affiliation>Carol Davila Univ Med &amp; Pharm, Dept Pharmaceut Microbiol, Fac Pharm, Bucharest, Romania</affiliation>
    </creator>
    <creator>
      <creatorName>Docea, A. O.</creatorName>
      <givenName>A. O.</givenName>
      <familyName>Docea</familyName>
      <affiliation>Univ Med &amp; Pharm, Dept Toxicol, Fac Pharm, Craiova, Romania</affiliation>
    </creator>
    <creator>
      <creatorName>Gofita, E.</creatorName>
      <givenName>E.</givenName>
      <familyName>Gofita</familyName>
      <affiliation>Univ Med &amp; Pharm, Dept Toxicol, Fac Pharm, Craiova, Romania</affiliation>
    </creator>
    <creator>
      <creatorName>Calina, D.</creatorName>
      <givenName>D.</givenName>
      <familyName>Calina</familyName>
      <affiliation>Univ Med &amp; Pharm, Dept Clin Pharmacol, Fac Pharm, Craiova, Romania</affiliation>
    </creator>
    <creator>
      <creatorName>Taitzoglou, I.</creatorName>
      <givenName>I.</givenName>
      <familyName>Taitzoglou</familyName>
      <affiliation>Aristotle Univ Thessaloniki, Sch Hlth Sci, Fac Vet Med, Dept Physiol, Thessaloniki, Greece</affiliation>
    </creator>
    <creator>
      <creatorName>Liesivuori, J.</creatorName>
      <givenName>J.</givenName>
      <familyName>Liesivuori</familyName>
      <affiliation>Univ Turku, Dept Pharmacol Drug Dev &amp; Therapeut, Turku, Finland</affiliation>
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    <creator>
      <creatorName>Liesivuori, J.</creatorName>
      <givenName>J.</givenName>
      <familyName>Liesivuori</familyName>
      <affiliation>Univ Turku, Dept Pharmacol Drug Dev &amp; Therapeut, Turku, Finland</affiliation>
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  <titles>
    <title>Simulating Real-Life Exposures To Uncover Possible Risks To Human Health: A Proposed Consensus For A Novel Methodological Approach</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/52521</alternateIdentifier>
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    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1177/0960327116681652</relatedIdentifier>
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  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In real life, consumers are exposed to complex mixtures of chemicals via food, water and commercial products consumption. Since risk assessment usually focuses on individual compounds, the current regulatory approach doesn't assess the overall risk of chemicals present in a mixture. This study will evaluate the cumulative toxicity of mixtures of different classes of pesticides and mixtures of different classes of pesticides together with food additives (FAs) and common consumer product chemicals using realistic doses after long-term exposure. Groups of Sprague Dawley (CD-SD) rats (20 males and 20 females) will be treated with mixtures of pesticides or mixtures of pesticides together with FAs and common consumer product chemicals in 0.0, 0.25 x acceptable daily intake (ADI)/tolerable daily intake (TDI), ADI/TDI and 5 x ADI/TDI doses for 104 weeks. All animals will be examined every day for signs of morbidity and mortality. Clinical chemistry hematological parameters, serum hormone levels, biomarkers of oxidative stress, cardiotoxicity, genotoxicity, urinalysis and echocardiographic tests will be assessed periodically at 6 month intervals. At 3-month intervals, ophthalmological examination, test for sensory reactivity to different types of stimuli, together with assessment of learning abilities and memory performance of the adult and ageing animals will be conducted. After 24 months, animals will be necropsied, and internal organs will be histopathologically examined. If the hypothesis of an increased risk or a new hazard not currently identified from cumulative exposure to multiple chemicals was observed, this will provide further information to public authorities and research communities supporting the need of replacing current single-compound risk assessment by a more robust cumulative risk assessment paradigm.</description>
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