1 Ocak 2017 Dergi makalesi Açık Erişim

Kirbay, Fatma Ozturk; Geyik, Caner; Guler, Emine; Yesiltepe, Ozan; Gumus, Zinar Pinar; Demirkol, Dilek Odaci; Coskunol, Hakan; Timur, Suna

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/51657</identifier>
  <creators>
    <creator>
      <creatorName>Kirbay, Fatma Ozturk</creatorName>
      <givenName>Fatma Ozturk</givenName>
      <familyName>Kirbay</familyName>
    </creator>
    <creator>
      <creatorName>Geyik, Caner</creatorName>
      <givenName>Caner</givenName>
      <familyName>Geyik</familyName>
    </creator>
    <creator>
      <creatorName>Guler, Emine</creatorName>
      <givenName>Emine</givenName>
      <familyName>Guler</familyName>
    </creator>
    <creator>
      <creatorName>Yesiltepe, Ozan</creatorName>
      <givenName>Ozan</givenName>
      <familyName>Yesiltepe</familyName>
    </creator>
    <creator>
      <creatorName>Gumus, Zinar Pinar</creatorName>
      <givenName>Zinar Pinar</givenName>
      <familyName>Gumus</familyName>
    </creator>
    <creator>
      <creatorName>Demirkol, Dilek Odaci</creatorName>
      <givenName>Dilek Odaci</givenName>
      <familyName>Demirkol</familyName>
    </creator>
    <creator>
      <creatorName>Coskunol, Hakan</creatorName>
      <givenName>Hakan</givenName>
      <familyName>Coskunol</familyName>
    </creator>
    <creator>
      <creatorName>Timur, Suna</creatorName>
      <givenName>Suna</givenName>
      <familyName>Timur</familyName>
    </creator>
  </creators>
  <titles>
    <title>Testing Of Bioactive-Nanovesicles On Hepatotoxicity Of Atypical Antipsychotics Via Digital Holography</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/51657</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.colsurfb.2017.01.006</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Atypical antipsychotic drugs induce hepatic toxicity. Thus, it is of importance to eliminate the side effects of these drugs. Herein we describe the preparation of nanoemulsions with a dietary supplement; wheat germ oil (WGO), to ameliorate the liver damage induced by clozapine and olanzapine. THLE-2 cell line was used as a model to investigate the effects of these nanoemulsions on cell viability as well as antioxidative efficiency after antipsychotic insult. In this context, a conventional cell culture method; MTT was used along with a novel cellular imaging technique called digital holography (DH) to evaluate cell viability. Obtained data confirmed that both clozapine and olanzapine induced the liver damage in in vitro model and WGO nanoemulsions were found to be effective on cells and eliminate the cytotoxic effects of these drugs. Briefly, this study has some outputs as follows; it showed that different dietary supplements can be used in such formulations instead of their pristine forms to increase bioavailability. Also, DH was successfully applied for the monitoring of cell viability and it could be a promising approach as the reactive-free cytotoxicity test. (C) 2017 Elsevier B.V. All rights reserved.</description>
  </descriptions>
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