1 Ocak 2017 Dergi makalesi Açık Erişim

Terzioglu-Usak, Sule; Negis, Yesim; Karabulut, Derya S.; Zaim, Merve; Isik, Sevim

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/51647</identifier>
  <creators>
    <creator>
      <creatorName>Terzioglu-Usak, Sule</creatorName>
      <givenName>Sule</givenName>
      <familyName>Terzioglu-Usak</familyName>
      <affiliation>Bezmialem Vakif Univ, Dept Med Biol, Fac Med, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Negis, Yesim</creatorName>
      <givenName>Yesim</givenName>
      <familyName>Negis</familyName>
      <affiliation>Bahcesehir Univ, Dept Med Biochem, Fac Med, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karabulut, Derya S.</creatorName>
      <givenName>Derya S.</givenName>
      <familyName>Karabulut</familyName>
      <affiliation>Namik Kemal St 59-8, TR-34310 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Zaim, Merve</creatorName>
      <givenName>Merve</givenName>
      <familyName>Zaim</familyName>
      <affiliation>Tuna St 51, TR-34040 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Isik, Sevim</creatorName>
      <givenName>Sevim</givenName>
      <familyName>Isik</familyName>
      <affiliation>EMC Technol Inc, Biotechnol Res Lab, ARGEM Bldg, TR-34320 Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Cellular Model Of Alzheimer'S Disease: A Beta(1-42) Peptide Induces Amyloid Deposition And A Decrease In Topo Isomerase Ii Beta And Nurr1 Expression</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/51647</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2174/1567205014666170117103217</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: DNA topoisomerase II beta (topo II beta) plays a crucial role in neural differentiation and axonogenesis. Inhibition of topo II beta activity in vitro and in vivo results in shorter axons and increased DNA damage. These molecular events also involve in Alzheimer's disease (AD); however, the role of topo II beta in the pathogenesis of AD remains to be elucidated.</description>
  </descriptions>
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