Dergi makalesi Açık Erişim
Doeppner, Thorsten R.; Doehring, Maria; Kaltwasser, Britta; Majid, Arshad; Lin, Fengyan; Bahr, Mathias; Kilic, Ertugrul; Hermann, Dirk M.
<?xml version='1.0' encoding='UTF-8'?> <record xmlns="http://www.loc.gov/MARC21/slim"> <leader>00000nam##2200000uu#4500</leader> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Doehring, Maria</subfield> <subfield code="u">Oberhavel Kliniken, Dept Internal Med, Oranienburg, Germany</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kaltwasser, Britta</subfield> <subfield code="u">Univ Duisburg Essen, Sch Med, Dept Neurol, Essen, Germany</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Majid, Arshad</subfield> <subfield code="u">Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield, S Yorkshire, England</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Lin, Fengyan</subfield> <subfield code="u">Jilin Univ, Affiliated Hosp 1, Ctr Canc, Changchun, Jilin, Peoples R China</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Bahr, Mathias</subfield> <subfield code="u">Univ Gottingen, Dept Neurol, Sch Med, Gottingen, Germany</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Kilic, Ertugrul</subfield> <subfield code="u">Istanbul Medipol Univ, Regenerat & Restorat Med Res Ctr, Istanbul, Turkey</subfield> </datafield> <datafield tag="700" ind1=" " ind2=" "> <subfield code="a">Hermann, Dirk M.</subfield> <subfield code="u">Univ Duisburg Essen, Sch Med, Dept Neurol, Essen, Germany</subfield> </datafield> <datafield tag="909" ind1="C" ind2="4"> <subfield code="p">MOLECULAR NEUROBIOLOGY</subfield> <subfield code="v">54</subfield> <subfield code="n">8</subfield> <subfield code="c">6061-6073</subfield> </datafield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="540" ind1=" " ind2=" "> <subfield code="a">Creative Commons Attribution</subfield> <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield> </datafield> <datafield tag="024" ind1=" " ind2=" "> <subfield code="a">10.1007/s12035-016-0137-3</subfield> <subfield code="2">doi</subfield> </datafield> <datafield tag="245" ind1=" " ind2=" "> <subfield code="a">Ischemic Post-Conditioning Induces Post-Stroke Neuroprotection via Hsp70-Mediated Proteasome Inhibition and Facilitates Neural Progenitor Cell Transplantation</subfield> </datafield> <datafield tag="100" ind1=" " ind2=" "> <subfield code="a">Doeppner, Thorsten R.</subfield> </datafield> <datafield tag="909" ind1="C" ind2="O"> <subfield code="o">oai:zenodo.org:51479</subfield> <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield> </datafield> <datafield tag="650" ind1="1" ind2="7"> <subfield code="2">opendefinition.org</subfield> <subfield code="a">cc-by</subfield> </datafield> <datafield tag="260" ind1=" " ind2=" "> <subfield code="c">2017-01-01</subfield> </datafield> <datafield tag="856" ind1="4" ind2=" "> <subfield code="u">https://aperta.ulakbim.gov.trrecord/51479/files/bib-2f27f757-340c-4a68-928b-65022b799d75.txt</subfield> <subfield code="z">md5:50097b325886bbcc90d77e35c1b4b210</subfield> <subfield code="s">307</subfield> </datafield> <datafield tag="542" ind1=" " ind2=" "> <subfield code="l">open</subfield> </datafield> <controlfield tag="005">20210315225710.0</controlfield> <controlfield tag="001">51479</controlfield> <datafield tag="980" ind1=" " ind2=" "> <subfield code="a">publication</subfield> <subfield code="b">article</subfield> </datafield> <datafield tag="520" ind1=" " ind2=" "> <subfield code="a">In view of the failure of pharmacological therapies, alternative strategies promoting post-stroke brain repair are needed. Post-conditioning is a potentially promising therapeutic strategy, which induces acute neuroprotection against ischemic injury. To elucidate longer lasting actions of ischemic post-conditioning, mice were exposed to a 60-min stroke and post-conditioning by an additional 10-min stroke that was induced 10 min after reperfusion onset. Animals were sacrificed 24 h or 28 days post-stroke. Post-conditioning reduced infarct volume and neurological deficits 24 h poststroke, enhancing blood-brain barrier integrity, reducing brain leukocyte infiltration, and reducing oxidative stress. On the molecular level, post-conditioning yielded increased Hsp70 expression, whereas nuclear factor (NF)-kappa B and proteasome activities were decreased. Reduced infarct volume and proteasome inhibition were reversed by Hsp70 knockdown, suggesting a critical role of the Hsp70 proteasome pathway in ischemic post-conditioning. The survival-promoting effects of ischemic post-conditioning, however, were not sustainable as neuroprotection and neurological recovery were lost 28 days post-stroke. Although angioneurogenesis was not increased by post-conditioning, the favorable extracellular milieu facilitated intracerebral transplantation of neural progenitor cells 6 h post-stroke, resulting in persisted neuroprotection and neurological recovery. Thus, post-conditioning might support brain repair processes, but in view of its transient, neuroprotection is unlikely useful as stroke therapy in its current form.</subfield> </datafield> </record>
Görüntülenme | 27 |
İndirme | 8 |
Veri hacmi | 2.5 kB |
Tekil görüntülenme | 26 |
Tekil indirme | 7 |