1 Ocak 2017 Dergi makalesi Açık Erişim

Uzunalli, Gozde; Mammadov, Rashad; Yesildal, Fatih; Alhan, Dogan; Ozturk, Serdar; Ozgurtas, Taner; Guler, Mustafa O.; Tekinay, Ayse B.

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/48361</identifier>
  <creators>
    <creator>
      <creatorName>Uzunalli, Gozde</creatorName>
      <givenName>Gozde</givenName>
      <familyName>Uzunalli</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Mammadov, Rashad</creatorName>
      <givenName>Rashad</givenName>
      <familyName>Mammadov</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yesildal, Fatih</creatorName>
      <givenName>Fatih</givenName>
      <familyName>Yesildal</familyName>
      <affiliation>Diyarbakir Mil Hosp, Dept Med Biochem, Diyarbakir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Alhan, Dogan</creatorName>
      <givenName>Dogan</givenName>
      <familyName>Alhan</familyName>
      <affiliation>Gulhane Mil Med Acad, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozturk, Serdar</creatorName>
      <givenName>Serdar</givenName>
      <familyName>Ozturk</familyName>
      <affiliation>Gulhane Mil Med Acad, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Ozgurtas, Taner</creatorName>
      <givenName>Taner</givenName>
      <familyName>Ozgurtas</familyName>
      <affiliation>Gulhane Mil Med Acad, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Guler, Mustafa O.</creatorName>
      <givenName>Mustafa O.</givenName>
      <familyName>Guler</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tekinay, Ayse B.</creatorName>
      <givenName>Ayse B.</givenName>
      <familyName>Tekinay</familyName>
      <affiliation>Bilkent Univ, Inst Mat Sci &amp; Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Angiogenic Heparin-Mimetic Peptide Nanofiber Gel Improves Regenerative Healing Of Acute Wounds</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/48361</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1021/acsbiomaterials.6b00165</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Wound repair in adult mammals typically ends with the formation of a scar, which prevents HI restoration of the function of the healthy tissue, although most of the wounded skin heals. Rapid and functional recovery of major wound injuries requires therapeutic approaches that can enhance the healing process via overcoming mechanical and biochemical problems. In this study, we showed that self-assembled heparin-mimetic peptide nanofiber gel was an effective bioactive wound dressing for the rapid and functional repair of full-thickness excisional wounds in the rat model. The bioactive gel-treated wounds exhibited increased angiogenesis (p &amp;lt; 0.05), re-epithelization (p &amp;lt; 0.05), skin appendage 'formation, and granulation tissue organization (p &amp;lt; 0.05) compared to sucrose treated samples. Increased blood vessel numbers in the gel-treated wounds on day 7 suggest that angiogenesis played a key role in improvement of tissue healing in bioactive gel-treated wounds. Overall, the angiogenic heparin-mimetic peptide nanofiber gel is a promising platform for enhancing the scar-free recovery of acute wounds.</description>
  </descriptions>
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