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Homology Modeling of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights into Isoenzyme-Specific Differences Using Molecular Docking Simulatons

Eren, Gokcen


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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/48061</identifier>
  <creators>
    <creator>
      <creatorName>Eren, Gokcen</creatorName>
      <givenName>Gokcen</givenName>
      <familyName>Eren</familyName>
      <affiliation>Gazi Univ, Dept Pharmaceut Chem, Fac Pharm, POB 06330, Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Homology Modeling Of Human Nicotinamide/Nicotinic Acid Mononucleotide Adenylyltransferase 2: Insights Into Isoenzyme-Specific Differences Using Molecular Docking Simulatons</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/48061</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.2174/1570180814666161110112859</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Background: Nicotinamide adenine dinucleotide (NAD) is an essential coenzyme that plays crucial roles in energy metabolism, DNA repair and cell death. Due to the high proliferation rate and the high energy necessity in cancer cells, NAD biosynthesis and salvage is required. Owing to the NAD importance in cancer cells, NAD salvage/recycling enzymes are targets for drug discovery.</description>
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