1 Ocak 2020 Dergi makalesi Açık Erişim

Oz, Umut Can; Toptas, Mete; Kucukturkmen, Berrin; Devrim, Burcu; Saka, Ongun Mehmet; Deveci, Mehmet Salih; Bilgili, Hasan; Unsal, Elif; Bozkir, Asuman

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/4801</identifier>
  <creators>
    <creator>
      <creatorName>Oz, Umut Can</creatorName>
      <givenName>Umut Can</givenName>
      <familyName>Oz</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Toptas, Mete</creatorName>
      <givenName>Mete</givenName>
      <familyName>Toptas</familyName>
      <affiliation>Bezmialem Univ, Fac Dent, Dept Periodontol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kucukturkmen, Berrin</creatorName>
      <givenName>Berrin</givenName>
      <familyName>Kucukturkmen</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Devrim, Burcu</creatorName>
      <givenName>Burcu</givenName>
      <familyName>Devrim</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Saka, Ongun Mehmet</creatorName>
      <givenName>Ongun Mehmet</givenName>
      <familyName>Saka</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Deveci, Mehmet Salih</creatorName>
      <givenName>Mehmet Salih</givenName>
      <familyName>Deveci</familyName>
      <affiliation>Hlth Sci Univ, Gulhane Med Fac, Pathol Dept, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bilgili, Hasan</creatorName>
      <givenName>Hasan</givenName>
      <familyName>Bilgili</familyName>
      <affiliation>Ankara Univ, Fac Vet Med, Dept Surg, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Unsal, Elif</creatorName>
      <givenName>Elif</givenName>
      <familyName>Unsal</familyName>
      <affiliation>Ankara Univ, Fac Dent, Dept Periodontol, Ankara, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bozkir, Asuman</creatorName>
      <givenName>Asuman</givenName>
      <familyName>Bozkir</familyName>
      <affiliation>Ankara Univ, Fac Pharm, Dept Pharmaceut Technol, TR-06560 Ankara, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Guided Bone Regeneration By The Development Of Alendronate Sodium Loaded In-Situ Gel And Membrane Formulations</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/4801</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejps.2020.105561</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Biocompatible materials applied in guided bone regeneration are needed to prevent leakage caused by the invasion of peripheral epithelium. (2.1) The aim of this study is to develop a thermosensitive in situ gel system containing alendronate sodium loaded PLGA nanoparticles and alendronate sodium loaded membranes for guided bone regeneration. Thermosensitive Pluronic F127 gel system was preferred to prevent soft tissue migration to the defect site and prolong the residence time of the nanoparticles in this region. In situ gel system was combined with membrane formulation to enhance bone regenaration activity. Efficacy of combination system was investigated by implanting in 0.5 x 0.5 cm critical size defect in tibia of New Zealand female rabbits. According to the histopathological results, fibroblast formations were found at defect area after 6 weeks of post implantation. In contrast, treatment with the combination of in-situ gel containing nanoparticles with membrane provided woven bone formation with mature bone after 4 weeks of post implantation. As a results, the combination of in-situ gel formulation containing alendronate sodium-loaded nanoparticles with membrane formulation could be effectively applided for guided bone regeneration.</description>
  </descriptions>
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