1 Ocak 2017 Dergi makalesi Açık Erişim

Caliskan, Ozum S.; Ekiz, Melis Sardan; Tekinay, Ayse B.; Guler, Mustafa O.

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  "@context": "https://schema.org/", 
  "@id": 47391, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey", 
      "name": "Caliskan, Ozum S."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey", 
      "name": "Ekiz, Melis Sardan"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey", 
      "name": "Tekinay, Ayse B."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Bilkent Univ, Inst Mat Sci & Nanotechnol, Natl Nanotechnol Res Ctr UNAM, TR-06800 Ankara, Turkey", 
      "name": "Guler, Mustafa O."
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Spatial organization of bioactive moieties in biological materials has significant impact on the function and efficiency of these systems. Here, we demonstrate the effect of spatial organization of functional groups including carboxylate, amine, and glucose functionalities by using self-assembled peptide amphiphile (PA) nanofibers as a bioactive scaffold. We show that presentation of bioactive groups on glycopeptide nanofibers affects mesenchymal stem cells (MSCs) in a distinct manner by means of adhesion, proliferation, and differentiation. Strikingly, when the glutamic acid is present in the glycopeptide backbone, the PA nanofibers specifically induced differentiation of MSCs into brown adipocytes in the absence of any differentiation medium as shown by lipid droplet accumulation and adipogenic gene marker expression analyses. This effect was not evident in the other glycopeptide nanofibers, which displayed the same functional groups but with different spatial organization. Brown adipocytes are attractive targets for obesity treatment and are found in trace amounts in adults, which also makes this specific glycopeptide nanofiber system an attractive tool to study molecular pathways of brown adipocyte formation.", 
  "headline": "Spatial Organization of Functional Groups on Bioactive Supramolecular Glycopeptide Nanofibers for Differentiation of Mesenchymal Stem Cells (MSCs) to Brown Adipogenesis", 
  "identifier": 47391, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Spatial Organization of Functional Groups on Bioactive Supramolecular Glycopeptide Nanofibers for Differentiation of Mesenchymal Stem Cells (MSCs) to Brown Adipogenesis", 
  "url": "https://aperta.ulakbim.gov.tr/record/47391"
}