1 Ocak 2017 Dergi makalesi Açık Erişim

Cetinkol, Yeliz; Sandalli, Cemal; Calgin, Mustafa Kerem; Yildirim, Arzu Altuncekic; Akyildiz, Esma; Karaman, Esin; Cicek, Aysegul Copur

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/47065</identifier>
  <creators>
    <creator>
      <creatorName>Cetinkol, Yeliz</creatorName>
      <givenName>Yeliz</givenName>
      <familyName>Cetinkol</familyName>
      <affiliation>Ordu Univ, Dept Med Microbiol, Fac Med, Ordu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sandalli, Cemal</creatorName>
      <givenName>Cemal</givenName>
      <familyName>Sandalli</familyName>
      <affiliation>Recep Tayyip Erdogan Univ, Fac Arts &amp; Sci, Dept Biol, Rize, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Calgin, Mustafa Kerem</creatorName>
      <givenName>Mustafa Kerem</givenName>
      <familyName>Calgin</familyName>
      <affiliation>Ordu Univ, Dept Med Microbiol, Fac Med, Ordu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yildirim, Arzu Altuncekic</creatorName>
      <givenName>Arzu Altuncekic</givenName>
      <familyName>Yildirim</familyName>
      <affiliation>Ordu Univ, Dept Infect Dis, Fac Med, Ordu, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Akyildiz, Esma</creatorName>
      <givenName>Esma</givenName>
      <familyName>Akyildiz</familyName>
      <affiliation>Recep Tayyip Erdogan Univ, Fac Arts &amp; Sci, Dept Biol, Rize, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Karaman, Esin</creatorName>
      <givenName>Esin</givenName>
      <familyName>Karaman</familyName>
      <affiliation>Recep Tayyip Erdogan Univ, Fac Arts &amp; Sci, Dept Biol, Rize, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Cicek, Aysegul Copur</creatorName>
      <givenName>Aysegul Copur</givenName>
      <familyName>Cicek</familyName>
      <affiliation>Recep Tayyip Erdogan Univ, Dept Med Microbiol, Fac Med, Rize, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>High Prevalence Of Ndm Metallo-Beta-Lactamase Among Esbl-Producing Escherichia Coli Isolates</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2017</publicationYear>
  <dates>
    <date dateType="Issued">2017-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/47065</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1556/030.63.2016.027</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Resistance to beta-lactams in Enterobacteriaceae has been increasing worldwide. This study aimed to determine the frequency of beta-lactamase genes and antibiotic resistance rates of 140 extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli isolates obtained from urinary tract infection in Ordu Province, Turkey. Isolates were identified by classic methods and by automated system. ESBL production was confirmed by double disk synergy test and antimicrobial susceptibility was investigated by disk diffusion method. All isolates were screened for beta-lactamase coding genes from three groups (A, B, and D) by polymerase chain reaction. The highest rate of susceptible isolates was observed for imipenem (IPM, 99.3%) and ertapenem (ETP, 97.9%), and the highest rate of resistant isolates was observed for cefuroxime (97.9%), ceftriaxone (97.2%), and cefazolin (90.7%). In our study, bl(aCTX-M1-like) group was the most prevalent beta-lactamase (n = 109), followed by bla(TEM) (n = 68), bla(CTX-M2) (n = 22), and bla(SHV) (n = 2). By contrast to low resistance rate to IPM and ETP, we determined bla(NDM) in 31 isolates (22.1%). In co-prevalence of bla(NDM-1) and ESBL-coding genes, a low carbapenem resistance was determined. Wecan confirm that bla(CTX-M1-types) are still the most frequent beta-lactamase coding gene in Turkey. Our study showed the highest prevalence of bla(NDM-1) metallo-beta-lactamase coding gene in ESBL-producing E. coli.</description>
  </descriptions>
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