1 Ocak 2017 Dergi makalesi Açık Erişim

Gokce, Evren H.; Tanriverdi, Sakine Tuncay; Eroglu, Ipek; Tsapis, Nicolas; Gokce, Goksel; Tekmen, Isil; Fattal, Elias; Ozer, Ozgen

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{
  "@context": "https://schema.org/", 
  "@id": 45759, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Pharmaceut Technol, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Gokce, Evren H."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Pharmaceut Technol, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Tanriverdi, Sakine Tuncay"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hacettepe Univ, Dept Basic Pharmaceut Sci, Fac Pharm, TR-06100 Ankara, Turkey", 
      "name": "Eroglu, Ipek"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Paris Saclay, Univ Paris Sud, CNRS, Inst Galien Paris Sud, F-92296 Chatenay Malabry, France", 
      "name": "Tsapis, Nicolas"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Fac Pharm, Dept Pharmacol, TR-35100 Izmir, Turkey", 
      "name": "Gokce, Goksel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Sch Med, Dept Histol & Embryol, TR-35340 Izmir, Turkey", 
      "name": "Tekmen, Isil"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Paris Saclay, Univ Paris Sud, CNRS, Inst Galien Paris Sud, F-92296 Chatenay Malabry, France", 
      "name": "Fattal, Elias"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ege Univ, Dept Pharmaceut Technol, Fac Pharm, TR-35100 Izmir, Turkey", 
      "name": "Ozer, Ozgen"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "An alternative formulation for the treatment of diabetic foot wounds that heal slowly is a requirement in pharmaceutical field. The aim of this study was to develop a dermal matrix consisting of skin proteins and lipids with an antioxidant that will enhance healing and balance the oxidative stress in the diabetic wound area due to the high levels of glucose. Thus a novel three dimensional collagen-laminin porous dermal matrix was developed by lyophilization. Resveratrol-loaded hyaluronic acid and dipalmitoylpho sphatidylcholine microparticles were combined with this dermal matrix. Characterization, in vitro release, microbiological and in vivo studies were performed. Spherical microparticles were obtained with a high RSV encapsulation efficacy. The microparticles were well dispersed in the dermal matrix from the surface to deeper layers. Collagenase degraded dermal matrix, however the addition of RSV loaded microparticles delayed the degradation time. The release of RSV was sustained and reached 70% after 6 h. Histological changes and antioxidant parameters in different treatment groups were investigated in full-thickness excision diabetic rat model. Collagen fibers were intense and improved by the presence of formulation without any signs of inflammation. The highest healing score was obtained with the dermal matrix impregnated with RSV-microparticles with an increased antioxidant activity. Collagenlaminin dermal matrix with RSV-microparticles was synergistically effective due to presence of skin components in the formulation and controlled release achieved. This combination is a safe and promising option for the treatment of diabetic wounds requiring long recovery. (C) 2017 Elsevier B.V. All rights reserved.", 
  "headline": "Wound healing effects of collagen-laminin dermal matrix impregnated with resveratrol loaded hyaluronic acid-DPPC microparticles in diabetic rats", 
  "identifier": 45759, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Wound healing effects of collagen-laminin dermal matrix impregnated with resveratrol loaded hyaluronic acid-DPPC microparticles in diabetic rats", 
  "url": "https://aperta.ulakbim.gov.tr/record/45759"
}