1 Ocak 2020 Dergi makalesi Açık Erişim

Erol, Meryem; Celik, Ismail; Temiz-Arpaci, Ozlem; Goker, Hakan; Kaynak-Onurdag, Fatma; Okten, Suzan

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
    <subfield code="o">oai:zenodo.org:4549</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">In this study, 15 new 1H-benzimidazole-5-carboxamidine derivative compounds that could be new antimicrobial agents were synthesized and their antimicrobial activities were determined using the microdilution method. When the activity results were examined, it was observed that the antibacterial effects of the new benzimidazole derivatives were weaker than standard drugs, but some derivatives showed significant efficacy against MRSA and VREF with the value of MIC: 8 mu g/ml compared to reference drugs. The antifungal effects of the compounds were found to be weaker compared to the reference drugs. Molecular docking studies of compounds and reference drugs used were performed against PBP4 and the active and allosteric site of PBP2a, and estimated ADME profiles were calculated. In addition, 2D and 3D interactions of N10, one of the most effective antimicrobial compounds compared to reference drugs, were demonstrated in both sites.</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Erol, Meryem</subfield>
    <subfield code="u">Erciyes Univ, Dept Pharmaceut Chem, Fac Pharm, TR-38280 Talas Kayseri, Turkey</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="z">md5:fd58770d1ec266e19b3dfa646f85fff3</subfield>
    <subfield code="s">264</subfield>
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/4549/files/bib-68ac34ce-b098-4895-82d6-4b12b4f083ae.txt</subfield>
  </datafield>
  <controlfield tag="005">20210315060021.0</controlfield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2020-01-01</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s00044-020-02621-5</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Synthesis, molecular docking and ADME prediction of some new benzimidazole carboxamidines derivatives as antimicrobial agents</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="v">29</subfield>
    <subfield code="p">MEDICINAL CHEMISTRY RESEARCH</subfield>
    <subfield code="c">2028-2038</subfield>
    <subfield code="n">11</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="a">cc-by</subfield>
    <subfield code="2">opendefinition.org</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Celik, Ismail</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Temiz-Arpaci, Ozlem</subfield>
    <subfield code="u">Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06560 Yenimahalle Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Goker, Hakan</subfield>
    <subfield code="u">Ankara Univ, Dept Pharmaceut Chem, Fac Pharm, TR-06560 Yenimahalle Ankara, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kaynak-Onurdag, Fatma</subfield>
    <subfield code="u">Fac Pharm, Dept Pharmaceut Microbiol, TR-22130 Iskender Edirne, Turkey</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Okten, Suzan</subfield>
    <subfield code="u">Fac Pharm, Dept Pharmaceut Microbiol, TR-22130 Iskender Edirne, Turkey</subfield>
  </datafield>
  <controlfield tag="001">4549</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
</record>