1 Ocak 2020 Dergi makalesi Açık Erişim

Izgordu, Huseyin; Sezer, Canan Vejselova; Comlekci, Emre; Kutlu, Hatice Mehtap

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/4531</identifier>
  <creators>
    <creator>
      <creatorName>Izgordu, Huseyin</creatorName>
      <givenName>Huseyin</givenName>
      <familyName>Izgordu</familyName>
      <affiliation>Eskisehir Tech Univ, Dept Biol, Fac Sci, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Sezer, Canan Vejselova</creatorName>
      <givenName>Canan Vejselova</givenName>
      <familyName>Sezer</familyName>
      <affiliation>Eskisehir Tech Univ, Dept Biol, Fac Sci, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Comlekci, Emre</creatorName>
      <givenName>Emre</givenName>
      <familyName>Comlekci</familyName>
      <affiliation>Eskisehir Tech Univ, Dept Biol, Fac Sci, Eskisehir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Kutlu, Hatice Mehtap</creatorName>
      <givenName>Hatice Mehtap</givenName>
      <familyName>Kutlu</familyName>
      <affiliation>Eskisehir Tech Univ, Dept Biol, Fac Sci, Eskisehir, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Characteristics Of Apoptosis Induction In Human Breast Cancer Cells Treated With A Ceramidase Inhibitor</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/4531</alternateIdentifier>
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  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s10616-020-00436-1</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Cancer is a complex disease with high mortality rates. Breast cancer is one of the most fatal diseases both for men and woman. Despite the positive developments on cancer treatment, a successful treatment agent/method has not been developed, yet. Recently, cancer research has been involved in sphingolipid metabolism. The key molecule here is ceramide. Ceramides mediate growth suppress, apoptosis and aging regulation. Ceramidases metabolize ceramide and decrease its level in cells and cause escape the death. Inhibition of ceramidases as new targets for cancer treatment is shown in the literature. Herein, we found that d-erythro-MAPP and its nanoparticle formulation, reduce the viability of MCF-7 cells in a dose-dependent manner with IC50 value of 4.4 mu M, and 15.6 mu M, respectively. Confocal and transmission electron microscopy results revealed apoptotic morphological and ultrastructural changes for both agents. Apoptosis and cell cycle arrest were supported by annexin-V, mitochondrial membrane potential changings and cell cycle analysis, respectively.</description>
  </descriptions>
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