1 Ocak 2020 Dergi makalesi Açık Erişim

Un, Rabia Nur; Masullo, Milena; Karayildirim, Tamer; Nalbantsoy, Ayse; Alankus, Ozgen; Piacente, Sonia

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/4529</identifier>
  <creators>
    <creator>
      <creatorName>Un, Rabia Nur</creatorName>
      <givenName>Rabia Nur</givenName>
      <familyName>Un</familyName>
      <affiliation>Ege Univ, Fac Sci, Chem Dept, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Masullo, Milena</creatorName>
      <givenName>Milena</givenName>
      <familyName>Masullo</familyName>
      <affiliation>Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II, I-84084 Salerno, Italy</affiliation>
    </creator>
    <creator>
      <creatorName>Karayildirim, Tamer</creatorName>
      <givenName>Tamer</givenName>
      <familyName>Karayildirim</familyName>
      <affiliation>Ege Univ, Fac Sci, Chem Dept, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Nalbantsoy, Ayse</creatorName>
      <givenName>Ayse</givenName>
      <familyName>Nalbantsoy</familyName>
      <affiliation>Ege Univ, Engn Fac, Dept Bioengn, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Alankus, Ozgen</creatorName>
      <givenName>Ozgen</givenName>
      <familyName>Alankus</familyName>
      <affiliation>Ege Univ, Fac Sci, Chem Dept, TR-35100 Izmir, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Piacente, Sonia</creatorName>
      <givenName>Sonia</givenName>
      <familyName>Piacente</familyName>
      <affiliation>Univ Salerno, Dipartimento Farm, Via Giovanni Paolo II, I-84084 Salerno, Italy</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Triterpene Glycosides From Silene Odontopetala</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2020</publicationYear>
  <dates>
    <date dateType="Issued">2020-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/4529</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.phytochem.2020.112404</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Silene species are known for their use in traditional medicine in treating several diseases. To the authors' knowledge there is no report on the chemical composition of S. odontopetala. Therefore, the phytochemical investigation of the methanol extract of S. odontopetala was carried out, leading to the isolation of six undescribed oleanane-type glycosides along with the known saponin azukisaponin IV. Their structures were elucidated by the analysis of 1D and 2D-NMR experiments, along with mass spectrometry analysis. The cytotoxic activity of oleanane-type saponins was evaluated against a small panel of cancer cell lines, including PC-3 (prostate carcinoma cells), MCF-7 (breast cancer cells), A549 (alveolar basal carcinoma cells), and HeLa (cervical carcinoma cells). Furthermore, the activity of isolated compounds against a normal cell line HEK-293, used for assessing their cytotoxicity, was evaluated.</description>
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