1 Ocak 2017 Dergi makalesi Açık Erişim

van Doorn, Linda J. C. van Waalwijk; Gispert, Juan D.; Kuiperij, H. Bea; Claassen, Jurgen A. H. R.; Arighi, Andrea; Baldeiras, Ines; Blennow, Kaj; Bozzali, Marco; Castelo-Branco, Miguel; Cavedo, Enrica; Emek-Savas, Derya D.; Eren, Erden; Eusebi, Paolo; Farotti, Lucia; Fenoglio, Chiara; Ormaechea, Juan Fortea; Freund-Levi, Yvonne; Frisoni, Giovanni B.; Galimberti, Daniela; Genc, Sermin; Genc, Sermin

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{
  "@context": "https://schema.org/", 
  "@id": 45133, 
  "@type": "ScholarlyArticle", 
  "creator": [
    {
      "@type": "Person", 
      "name": "van Doorn, Linda J. C. van Waalwijk"
    }, 
    {
      "@type": "Person", 
      "name": "Gispert, Juan D."
    }, 
    {
      "@type": "Person", 
      "name": "Kuiperij, H. Bea"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Radboud Univ Nijmegen, Med Ctr, Radboud Alzheimer Ctr, Donders Inst Brain Cognit & Behav,Dept Geriat, Nijmegen, Netherlands", 
      "name": "Claassen, Jurgen A. H. R."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy", 
      "name": "Arighi, Andrea"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Ctr Hosp Coimbra, Ctr Neurosci & Cell Biol CNC IBILI, Fac Med, Coimbra, Portugal", 
      "name": "Baldeiras, Ines"
    }, 
    {
      "@type": "Person", 
      "name": "Blennow, Kaj"
    }, 
    {
      "@type": "Person", 
      "affiliation": "IRCCS Santa Lucia Fdn, Neuroimaging Lab, Rome, Italy", 
      "name": "Bozzali, Marco"
    }, 
    {
      "@type": "Person", 
      "name": "Castelo-Branco, Miguel"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Pierre & Marie Curie UPMC Paris 06, Sorbonne Univ,AXA Res Fund & UPMC Chair, Hop Pitie Salpetriere,CNRS,Dept Neurol, Inst Memoire & Malad Alzheimer,IM2A,Inst Cerveau, Blvd Hop, F-75013 Paris, France", 
      "name": "Cavedo, Enrica"
    }, 
    {
      "@type": "Person", 
      "name": "Emek-Savas, Derya D."
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Izmir Biomed & Genome Inst, Hlth Sci Inst, Dept Neurosci, Izmir, Turkey", 
      "name": "Eren, Erden"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Perugia, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy", 
      "name": "Eusebi, Paolo"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Perugia, Ctr Memory Disturbances, Neurol Sect, Perugia, Italy", 
      "name": "Farotti, Lucia"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Univ Milan, Fdn Ca Granda, IRCCS Osped Policlin, Milan, Italy", 
      "name": "Fenoglio, Chiara"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Hosp Sant Pau, Dept Neurol, Barcelona, Spain", 
      "name": "Ormaechea, Juan Fortea"
    }, 
    {
      "@type": "Person", 
      "name": "Freund-Levi, Yvonne"
    }, 
    {
      "@type": "Person", 
      "name": "Frisoni, Giovanni B."
    }, 
    {
      "@type": "Person", 
      "name": "Galimberti, Daniela"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Izmir Biomed & Genome Inst, Hlth Sci Inst, Dept Neurosci, Izmir, Turkey", 
      "name": "Genc, Sermin"
    }, 
    {
      "@type": "Person", 
      "affiliation": "Dokuz Eylul Univ, Izmir Biomed & Genome Inst, Hlth Sci Inst, Dept Neurosci, Izmir, Turkey", 
      "name": "Genc, Sermin"
    }
  ], 
  "datePublished": "2017-01-01", 
  "description": "Cerebrospinal fluid (CSF) biomarkers may support the diagnosis of Alzheimer's disease (AD). We studied if the diagnostic power of AD CSF biomarker concentrations, i.e., A beta(42), total tau (t-tau), and phosphorylated tau (p-tau), is affected by differences in lateral ventricular volume (VV), using CSF biomarker data and magnetic resonance imaging (MRI) scans of 730 subjects, from 13 European Memory Clinics. We developed a Matlab-algorithm for standardized automated segmentation analysis of T1 weighted MRI scans in SPM8 for determining VV, and computed its ratio with total intracranial volume (TIV) as proxy for total CSF volume. The diagnostic power of CSF biomarkers (and their combination), either corrected for VV/TIV ratio or not, was determined by ROC analysis. CSF A beta(42) levels inversely correlated to VV/TIV in the whole study population (A beta(42): r = -0.28; p < 0.0001). For CSF t-tau and p-tau, this association only reached statistical significance in the combined MCI and AD group (t-tau: r = -0.15; p-tau: r = -0.13; both p < 0.01). Correction for differences in VV/TIV improved the differentiation of AD versus controls based on CSF A beta(42) alone (AUC: 0.75 versus 0.81) or in combination with t-tau (AUC: 0.81 versus 0.91). In conclusion, differences in VV may be an important confounder in interpreting CSF A beta(42) levels.", 
  "headline": "Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes", 
  "identifier": 45133, 
  "image": "https://aperta.ulakbim.gov.tr/static/img/logo/aperta_logo_with_icon.svg", 
  "license": "http://www.opendefinition.org/licenses/cc-by", 
  "name": "Improved Cerebrospinal Fluid-Based Discrimination between Alzheimer's Disease Patients and Controls after Correction for Ventricular Volumes", 
  "url": "https://aperta.ulakbim.gov.tr/record/45133"
}