1 Ocak 2009 Dergi makalesi Açık Erişim

Horvat, Sandor; Feher, Andras; Wolburg, Hartwig; Peter Sipos; Veszelka, Szilvia; Toth, Andrea; Lorand Kis; Anita Kurunczi; Gabor Balogh; Levente Kuerti; Eros, Istvan; Szabo-Revesz, Piroska; Deli, Maria A.

DataCite XML

<?xml version='1.0' encoding='utf-8'?>
<resource xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns="http://datacite.org/schema/kernel-4" xsi:schemaLocation="http://datacite.org/schema/kernel-4 http://schema.datacite.org/meta/kernel-4.1/metadata.xsd">
  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/38723</identifier>
  <creators>
    <creator>
      <creatorName>Horvat, Sandor</creatorName>
      <givenName>Sandor</givenName>
      <familyName>Horvat</familyName>
    </creator>
    <creator>
      <creatorName>Feher, Andras</creatorName>
      <givenName>Andras</givenName>
      <familyName>Feher</familyName>
      <affiliation>Univ Szeged, Dept Pharmaceut Technol, Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Wolburg, Hartwig</creatorName>
      <givenName>Hartwig</givenName>
      <familyName>Wolburg</familyName>
      <affiliation>Univ Tubingen, Inst Pathol, D-7400 Tubingen, Germany</affiliation>
    </creator>
    <creator>
      <creatorName>Peter Sipos</creatorName>
      <affiliation>Univ Szeged, Dept Pharmaceut Technol, Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Veszelka, Szilvia</creatorName>
      <givenName>Szilvia</givenName>
      <familyName>Veszelka</familyName>
      <affiliation>Hungarian Acad Sci, Inst Biophys, Biol Res Ctr, Mol Neurobiol Lab, H-6726 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Toth, Andrea</creatorName>
      <givenName>Andrea</givenName>
      <familyName>Toth</familyName>
      <affiliation>Hungarian Acad Sci, Inst Biophys, Biol Res Ctr, Mol Neurobiol Lab, H-6726 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Lorand Kis</creatorName>
      <affiliation>Hungarian Acad Sci, Inst Biophys, Biol Res Ctr, Mol Neurobiol Lab, H-6726 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Anita Kurunczi</creatorName>
      <affiliation>Hungarian Acad Sci, Inst Biophys, Biol Res Ctr, Mol Neurobiol Lab, H-6726 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Gabor Balogh</creatorName>
      <affiliation>Hungarian Acad Sci, Inst Biochem, Biol Res Ctr, H-6726 Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Levente Kuerti</creatorName>
      <affiliation>Univ Szeged, Dept Pharmaceut Technol, Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Eros, Istvan</creatorName>
      <givenName>Istvan</givenName>
      <familyName>Eros</familyName>
      <affiliation>Univ Szeged, Dept Pharmaceut Technol, Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Szabo-Revesz, Piroska</creatorName>
      <givenName>Piroska</givenName>
      <familyName>Szabo-Revesz</familyName>
      <affiliation>Univ Szeged, Dept Pharmaceut Technol, Szeged, Hungary</affiliation>
    </creator>
    <creator>
      <creatorName>Deli, Maria A.</creatorName>
      <givenName>Maria A.</givenName>
      <familyName>Deli</familyName>
      <affiliation>Hungarian Acad Sci, Inst Biophys, Biol Res Ctr, Mol Neurobiol Lab, H-6726 Szeged, Hungary</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Sodium Hyaluronate As A Mucoadhesive Component In Nasal Formulation Enhances Delivery Of Molecules To Brain Tissue</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2009</publicationYear>
  <dates>
    <date dateType="Issued">2009-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/38723</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1016/j.ejpb.2008.10.009</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Intranasal administration of molecules has been investigated as a non-invasive way for delivery of drugs to the brain in the last decade. Circumvention of both the blood-brain barrier and the first-pass elimination by the liver and gastrointestinal tract is considered as the main advantages of this method. Because of the rapid mucociliary clearance in the nasal cavity, bioadhesive formulations are needed for effective targeting. Our goal was to develop a formulation containing sodium hyaluronate, a well-known mucoadhesive molecule, in combination with a non-ionic surfactant to enhance the delivery of hydrophilic compounds to the brain via the olfactory route. Fluorescein isothiocyanate-labeled 4 kDa dextran (FD-4), used as a test molecule, was administered nasally in different formulations to Wistar rats, and detected in brain areas by fluorescent spectrophotometry. Hyaluronan increased the viscosity of the vehicles and slowed down the in vitro release of FD-4. Significantly higher FD-4 transport could be measured in the majority of brain areas examined, including olfactory bulb, frontal and parietal cortex, hippocampus, cerebellum, midbrain and pons, when the vehicle contained hyaluronan in combination with absorption enhancer. The highest concentrations of FD-4 could be detected in the olfactory bulbs, frontal and parietal cortex 4 h after nasal administration in the mucoadhesive formulation. Intravenous administration of a hundred times higher dose of FD-4 resulted in a lower brain penetration as compared to nasal formulations. Morphological examination of the olfactory system revealed no toxicity of the vehicles. Hyaluronan, a non-toxic biomolecule used as a mucoadhesive in a nasal formulation, increased the brain penetration of a hydrophilic compound, the size of a peptide, via the nasal route. (C) 2008 Elsevier B.V. All rights reserved.</description>
  </descriptions>
</resource>