1 Ocak 2008 Dergi makalesi Açık Erişim

Sevimli, Alper; Misirlioglu, Deniz; Yagci, Artay; Bulbul, Aziz; Yilmaztepe, Arzu; Altunbas, Korhan

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/37535</identifier>
  <creators>
    <creator>
      <creatorName>Sevimli, Alper</creatorName>
      <givenName>Alper</givenName>
      <familyName>Sevimli</familyName>
      <affiliation>Afyon Kocatepe Univ, Fac Vet Med, Dept Pathol, TR-03200 Afyon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Misirlioglu, Deniz</creatorName>
      <givenName>Deniz</givenName>
      <familyName>Misirlioglu</familyName>
      <affiliation>Uludag Univ, Fac Vet Med, Dept Pathol, TR-16059 Gorukle, Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yagci, Artay</creatorName>
      <givenName>Artay</givenName>
      <familyName>Yagci</familyName>
      <affiliation>Afyon Kocatepe Univ, Fac Vet Med, Dept Histol &amp; Embriyol, TR-03200 Afyon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bulbul, Aziz</creatorName>
      <givenName>Aziz</givenName>
      <familyName>Bulbul</familyName>
      <affiliation>Afyon Kocatepe Univ, Dept Physiol, Fac Vet Med, TR-03200 Afyon, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Yilmaztepe, Arzu</creatorName>
      <givenName>Arzu</givenName>
      <familyName>Yilmaztepe</familyName>
      <affiliation>Uludag Univ, Fac Med, Dept Biochem, TR-16059 Bursa, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Altunbas, Korhan</creatorName>
      <givenName>Korhan</givenName>
      <familyName>Altunbas</familyName>
      <affiliation>Afyon Kocatepe Univ, Fac Vet Med, Dept Histol &amp; Embriyol, TR-03200 Afyon, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>The Role Of Chicken Il-1 Beta, Il-6 And Tnf-Alpha In The Occurrence Of Amyloid Arthropathy</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2008</publicationYear>
  <dates>
    <date dateType="Issued">2008-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/37535</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1007/s11259-007-9034-6</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">In this study, the roles of IL-1 beta, IL-6 and TNF-alpha in amyloid arthropathic chickens with variable amounts (severe, moderate and mild) of amyloid accumulation were investigated. The presence and the levels of cytokines were evaluated in serum and in joint tissues by using ELISA and immunohistochemistry, respectively. One hundred brown layer chicks were allocated into four groups and intra-articular injections of Freund's adjuvant were used to induce amyloid arthropathy in Groups II, III and IV. Vitamin A in group II, and methylprednisolone in Group IV were added to enhance and to reduce the severity of amyloidosis, respectively. At the end of the study, a positive correlation was observed among the incidence and severity of amyloidosis, the serum amyloid A levels and the IL-1 beta values both in the serum and tissues. Elevation in the tissue TNF-alpha levels in parallel with the severity of amyloidosis has also been noted.</description>
  </descriptions>
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