1 Ocak 2021 Dergi makalesi Açık Erişim

Hogberg, Helena T.; da Silveira E Sa, Rita de Cassia; Kleensang, Andre; Bouhifd, Mounir; Cemiloglu Ulker, Ozge; Smirnova, Lena; Behl, Mamta; Maertens, Alexandra; Zhao, Liang; Hartung, Thomas

MARC21 XML

<?xml version='1.0' encoding='UTF-8'?>
<record xmlns="http://www.loc.gov/MARC21/slim">
  <leader>00000nam##2200000uu#4500</leader>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">da Silveira E Sa, Rita de Cassia</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Kleensang, Andre</subfield>
    <subfield code="u">Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing CAAT, Baltimore, MD 21205 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Bouhifd, Mounir</subfield>
    <subfield code="u">Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing CAAT, Baltimore, MD 21205 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Cemiloglu Ulker, Ozge</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Smirnova, Lena</subfield>
    <subfield code="u">Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing CAAT, Baltimore, MD 21205 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Behl, Mamta</subfield>
    <subfield code="u">NIEHS, Natl Toxicol Program, Durham, NC USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Maertens, Alexandra</subfield>
    <subfield code="u">Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing CAAT, Baltimore, MD 21205 USA</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Zhao, Liang</subfield>
  </datafield>
  <datafield tag="700" ind1=" " ind2=" ">
    <subfield code="a">Hartung, Thomas</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="4">
    <subfield code="p">ARCHIVES OF TOXICOLOGY</subfield>
    <subfield code="v">95</subfield>
    <subfield code="n">1</subfield>
    <subfield code="c">207-228</subfield>
  </datafield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="540" ind1=" " ind2=" ">
    <subfield code="a">Creative Commons Attribution</subfield>
    <subfield code="u">http://www.opendefinition.org/licenses/cc-by</subfield>
  </datafield>
  <datafield tag="024" ind1=" " ind2=" ">
    <subfield code="a">10.1007/s00204-020-02903-2</subfield>
    <subfield code="2">doi</subfield>
  </datafield>
  <datafield tag="245" ind1=" " ind2=" ">
    <subfield code="a">Organophosphorus flame retardants are developmental neurotoxicants in a rat primary brainsphere in vitro model</subfield>
  </datafield>
  <datafield tag="100" ind1=" " ind2=" ">
    <subfield code="a">Hogberg, Helena T.</subfield>
    <subfield code="u">Johns Hopkins Bloomberg Sch Publ Hlth, Ctr Alternat Anim Testing CAAT, Baltimore, MD 21205 USA</subfield>
  </datafield>
  <datafield tag="909" ind1="C" ind2="O">
    <subfield code="o">oai:zenodo.org:3667</subfield>
    <subfield code="p">user-tubitak-destekli-proje-yayinlari</subfield>
  </datafield>
  <datafield tag="650" ind1="1" ind2="7">
    <subfield code="2">opendefinition.org</subfield>
    <subfield code="a">cc-by</subfield>
  </datafield>
  <datafield tag="260" ind1=" " ind2=" ">
    <subfield code="c">2021-01-01</subfield>
  </datafield>
  <datafield tag="856" ind1="4" ind2=" ">
    <subfield code="u">https://aperta.ulakbim.gov.trrecord/3667/files/bib-2d91083d-4808-47f6-b472-d81621d4c6c7.txt</subfield>
    <subfield code="z">md5:80585c0a1eec402910e490dc99c8dbf0</subfield>
    <subfield code="s">304</subfield>
  </datafield>
  <datafield tag="542" ind1=" " ind2=" ">
    <subfield code="l">open</subfield>
  </datafield>
  <controlfield tag="005">20210315054849.0</controlfield>
  <controlfield tag="001">3667</controlfield>
  <datafield tag="980" ind1=" " ind2=" ">
    <subfield code="a">publication</subfield>
    <subfield code="b">article</subfield>
  </datafield>
  <datafield tag="520" ind1=" " ind2=" ">
    <subfield code="a">Due to regulatory bans and voluntary substitutions, halogenated polybrominated diphenyl ether (PBDE) flame retardants (FR) are increasingly substituted by mainly organophosphorus FR (OPFR). Leveraging a 3D rat primary neural organotypic in vitro model (rat brainsphere), we compare developmental neurotoxic effects of BDE-47-the most abundant PBDE congener-with four OPFR (isopropylated phenyl phosphate-IPP, triphenyl phosphate-TPHP, isodecyl diphenyl phosphate-IDDP, and tricresyl phosphate (also known as trimethyl phenyl phosphate)-TMPP). Employing mass spectroscopy-based metabolomics and transcriptomics, we observe at similar human-relevant non-cytotoxic concentrations (0.1-5 mu M) stronger developmental neurotoxic effects by OPFR. This includes toxicity to neurons in the low mu M range; all FR decrease the neurotransmitters glutamate and GABA (except BDE-47 and TPHP). Furthermore,n-acetyl aspartate (NAA), considered a neurologic diagnostic molecule, was decreased by all OPFR. At similar concentrations, the FR currently in use decreased plasma membrane dopamine active transporter expression, while BDE-47 did not. Several findings suggest astrogliosis induced by the OPFR, but not BDE-47. At the 5 mu M concentrations, the OPFR more than BDE-47 interfered with myelination. An increase of cytokine gene and receptor expressions suggests that exposure to OPFR may induce an inflammatory response. Pathway/category overrepresentation shows disruption in 1) transmission of action potentials, cell-cell signaling, synaptic transmission, receptor signaling, (2) immune response, inflammation, defense response, (3) cell cycle and (4) lipids metabolism and transportation. Taken together, this appears to be a case of regretful substitution with substances not less developmentally neurotoxic in a primary rat 3D model.</subfield>
  </datafield>
</record>