1 Ocak 2018 Dergi makalesi Açık Erişim

da Silva, Cicera Simoni; Goncalves de Lima, Rita de Cassia; Elekofehinti, Olusola Olalekan; Ogunbolude, Yetunde; Duarte, Antonia Eliene; Teixeira Rocha, Joao Batista; Alencar de Menezes, Irwin Rose; Barros, Luiz Marivando; Tsopmo, Appolinaire; Lukong, Kiven Erique; Kamdem, Jean Paul

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      {
        "affiliation": "Reg Univ Cariri, Dept Biol Sci, Campus Pimenta, BR-63105000 Crato, Ceara, Brazil", 
        "name": "da Silva, Cicera Simoni"
      }, 
      {
        "affiliation": "Reg Univ Cariri, Dept Biol Sci, Campus Pimenta, BR-63105000 Crato, Ceara, Brazil", 
        "name": "Goncalves de Lima, Rita de Cassia"
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      {
        "name": "Elekofehinti, Olusola Olalekan"
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      {
        "affiliation": "Univ Saskatchewan, Coll Med, Dept Biochem, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada", 
        "name": "Ogunbolude, Yetunde"
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      {
        "affiliation": "Reg Univ Cariri, Dept Biol Sci, Campus Pimenta, BR-63105000 Crato, Ceara, Brazil", 
        "name": "Duarte, Antonia Eliene"
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      {
        "affiliation": "Univ Fed Santa Maria, CCNE, Dept Bioquim & Biol Mol, BR-97105900 Santa Maria, RS, Brazil", 
        "name": "Teixeira Rocha, Joao Batista"
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      {
        "affiliation": "Univ Reg Cariri, Mol Chem & Pharmacol Lab, Crato, CE, Brazil", 
        "name": "Alencar de Menezes, Irwin Rose"
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        "affiliation": "Reg Univ Cariri, Dept Biol Sci, Campus Pimenta, BR-63105000 Crato, Ceara, Brazil", 
        "name": "Barros, Luiz Marivando"
      }, 
      {
        "affiliation": "Carleton Univ, Inst Biochem, Food Sci & Nutr Program, 1125 Colonel By Dr, Ottawa, ON K1S 5B6, Canada", 
        "name": "Tsopmo, Appolinaire"
      }, 
      {
        "affiliation": "Univ Saskatchewan, Coll Med, Dept Biochem, 107 Wiggins Rd, Saskatoon, SK S7N 5E5, Canada", 
        "name": "Lukong, Kiven Erique"
      }, 
      {
        "affiliation": "Reg Univ Cariri, Dept Biol Sci, Campus Pimenta, BR-63105000 Crato, Ceara, Brazil", 
        "name": "Kamdem, Jean Paul"
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    "description": "The effects of caffeine supplementation is well documented in conventional animal models, however, in the lobster cockroaches Nauphoeta cinerea, they have not been reported. Thus, the aim of this study was to investigate the locomotor behavior and biochemical endpoints in the head of the nymphs of N. cinerea following 60 days exposure to food supplemented with 0, 0.5, 1.0, 2.5, 5.0 and 10.0 mg of caffeine/g of diet. The analysis of the locomotor behavior using the video-tracking software, Any-maze, for 12 min revealed that caffeine supplementation caused significant behavioral improvement. There was increase in distance travelled, velocity, frequency of rotation and turn angle (stereotypical behavior such as circling movements), and this was supported by the representative track plots of the path travelled by cockroaches in the open-field arena. In addition, caffeine supplementation markedly increased total thiol and non-protein thiol glutathione (GSH) levels in the heads of cockroaches, and this was in parallel with significant reduction of lipid peroxidation and free Fe(II) content. Taking together, our results indicate that long-term caffeine supplementation may exert preventive effects against oxidative stress and support the use of N. cinerea as an efficient alternative model to assess the efficacy of food molecules.", 
    "doi": "10.1016/j.cbi.2018.01.011", 
    "has_grant": false, 
    "journal": {
      "pages": "77-84", 
      "title": "CHEMICO-BIOLOGICAL INTERACTIONS", 
      "volume": "282"
    }, 
    "license": {
      "id": "cc-by"
    }, 
    "publication_date": "2018-01-01", 
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    "title": "Caffeine-supplemented diet modulates oxidative stress markers and improves locomotor behavior in the lobster cockroach Nauphoeta cinerea"
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