1 Ocak 2018 Dergi makalesi Açık Erişim

Baykan, Betul; Tuncer, Ozlem Gungor; Vanli-Yavuz, Ebru Nur; Kirac, Leyla Baysal; Gundogdu, Gokcen; Bebek, Nerses; Gurses, Candan; Altindag, Ebru; Tuzun, Erdem

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  <identifier identifierType="URL">https://aperta.ulakbim.gov.tr/record/35917</identifier>
  <creators>
    <creator>
      <creatorName>Baykan, Betul</creatorName>
      <givenName>Betul</givenName>
      <familyName>Baykan</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tuncer, Ozlem Gungor</creatorName>
      <givenName>Ozlem Gungor</givenName>
      <familyName>Tuncer</familyName>
      <affiliation>Istanbul Bilim Univ, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Vanli-Yavuz, Ebru Nur</creatorName>
      <givenName>Ebru Nur</givenName>
      <familyName>Vanli-Yavuz</familyName>
    </creator>
    <creator>
      <creatorName>Kirac, Leyla Baysal</creatorName>
      <givenName>Leyla Baysal</givenName>
      <familyName>Kirac</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gundogdu, Gokcen</creatorName>
      <givenName>Gokcen</givenName>
      <familyName>Gundogdu</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Pathol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Bebek, Nerses</creatorName>
      <givenName>Nerses</givenName>
      <familyName>Bebek</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Gurses, Candan</creatorName>
      <givenName>Candan</givenName>
      <familyName>Gurses</familyName>
      <affiliation>Istanbul Univ, Istanbul Fac Med, Dept Neurol, TR-34093 Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Altindag, Ebru</creatorName>
      <givenName>Ebru</givenName>
      <familyName>Altindag</familyName>
      <affiliation>Istanbul Bilim Univ, Dept Neurol, Istanbul, Turkey</affiliation>
    </creator>
    <creator>
      <creatorName>Tuzun, Erdem</creatorName>
      <givenName>Erdem</givenName>
      <familyName>Tuzun</familyName>
      <affiliation>Istanbul Univ, Inst Expt Med Res, Dept Neurosci, Istanbul, Turkey</affiliation>
    </creator>
  </creators>
  <titles>
    <title>Delta Brush Pattern Is Not Unique To Nmdar Encephalitis: Evaluation Of Two Independent Long-Term Eeg Cohorts</title>
  </titles>
  <publisher>Aperta</publisher>
  <publicationYear>2018</publicationYear>
  <dates>
    <date dateType="Issued">2018-01-01</date>
  </dates>
  <resourceType resourceTypeGeneral="Text">Journal article</resourceType>
  <alternateIdentifiers>
    <alternateIdentifier alternateIdentifierType="url">https://aperta.ulakbim.gov.tr/record/35917</alternateIdentifier>
  </alternateIdentifiers>
  <relatedIdentifiers>
    <relatedIdentifier relatedIdentifierType="DOI" relationType="IsIdenticalTo">10.1177/1550059417693168</relatedIdentifier>
  </relatedIdentifiers>
  <rightsList>
    <rights rightsURI="http://www.opendefinition.org/licenses/cc-by">Creative Commons Attribution</rights>
    <rights rightsURI="info:eu-repo/semantics/openAccess">Open Access</rights>
  </rightsList>
  <descriptions>
    <description descriptionType="Abstract">Purpose. Although its specificity has not previously been investigated in other cohorts, delta brush pattern (DBP) is increasingly reported in the EEGs of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis. Methods. We aimed to investigate the DBP in the EEGs of 2 cohorts; patients with change in consciousness for various causes monitored in the intensive care unit (ICU) (n = 106) and patients with mesial temporal lobe epilepsy (MTLE) with or without antineuronal antibodies (n = 76). Results. These patients were investigated for the presence of DBP, defined as an EEG pattern characterized by delta activity at 1 to 3 Hz with superimposed bursts of rhythmic 12- to 30-Hz activity. Two investigators blindfolded for the clinical and immunological data independently analyzed the EEGs for recognition of this pattern. An EEG picture compatible with DBP was observed in 4 patients; only 1 of them (1.3%) belonged to the MTLE group. She did not bear any of the investigated autoantibodies and was seizure-free after epilepsy surgery. In the ICU group, there were 3 additional patients showing DBP with various diagnoses such as hypoxic encephalopathy, brain tumor, stroke, and metabolic derangements. All of them had died in 1-month period. Conclusions. Our results underlined that DBP is not unique to NMDAR encephalitis; it may very rarely occur in MTLE with good prognosis after surgery and second, in ICU patients who have high mortality rate. Therefore, the presence of this pattern should alert the clinician for NMDAR encephalitis but other possible etiologies should not be ignored.</description>
  </descriptions>
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