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Activation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines

Cakmak, Osman; Okten, Salih; Alimli, Dilek; Saddiqa, Aisha; Ersanli, Cem Cuneyt


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{
  "DOI": "10.24820/ark.5550190.p010.374", 
  "abstract": "Quinoline forms the key skeletal component of a number of important natural products and pharmacologically-active compounds. Despite a tremendous amount of research pertaining to the derivatization of quinoline, very few general synthetic routes are described in the literature starting from quinoline or tetrahydroquinoline. A simple and convenient method for the polyfunctionalization of quinolines via nitration of bromoquinolines has been developed. This method represents a new synthetic approach to convert brominated nitroquinoline derivatives into useful cyclic amines via nucleophilic-substitution (SNAr) reaction.", 
  "author": [
    {
      "family": "Cakmak", 
      "given": " Osman"
    }, 
    {
      "family": "Okten", 
      "given": " Salih"
    }, 
    {
      "family": "Alimli", 
      "given": " Dilek"
    }, 
    {
      "family": "Saddiqa", 
      "given": " Aisha"
    }, 
    {
      "family": "Ersanli", 
      "given": " Cem Cuneyt"
    }
  ], 
  "container_title": "ARKIVOC", 
  "id": "33959", 
  "issued": {
    "date-parts": [
      [
        2018, 
        1, 
        1
      ]
    ]
  }, 
  "page": "362-374", 
  "title": "Activation of 6-bromoquinoline by nitration: synthesis of morpholinyl and piperazinyl quinolines", 
  "type": "article-journal"
}
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