Dergi makalesi Açık Erişim

p38 Mitogen-Activated Protein Kinase is Involved in the Pathogenesis of Endometriosis by Modulating Inflammation, but not Cell Survival

2018    Cakmak, Hakan; Seval-Celik, Yasemin; Arlier, Sefa; Guzeloglu-Kayisli, Ozlem; Schatz, Frederick; Arici, Aydin; Kayisli, Umit A.

Background: Local pro-inflammatory environment and enhanced cell survival contribute to the endometriosis development. A serine/threonine kinase p38 mitogen-activated protein kinase (MAPK) mediates intracellular signaling of cytokine production, cell proliferation, and apoptosis in different cell types. The current study compares p38 MAPK activity in normal endometrium and endometriosis, and assesses role(s) of p38 MAPK on cytokine production and cell survival in endometriosis.